Tybamate

Summary

Tybamate (INN; Solacen, Tybatran, Effisax) is an anxiolytic of the carbamate family.[1] It is a prodrug for meprobamate in the same way as the better known drug carisoprodol. It has liver enzyme inducing effects similar to those of phenobarbital but much weaker.[2]

Tybamate
Clinical data
ATC code
  • none
Identifiers
  • [2-(Carbamoyloxymethyl)-2-methylpentyl] N-butylcarbamate
CAS Number
  • 4268-36-4 checkY
PubChem CID
  • 20266
ChemSpider
  • 19092 ☒N
UNII
  • 3875LLL8M8
KEGG
  • D06260 checkY
CompTox Dashboard (EPA)
  • DTXSID7023728 Edit this at Wikidata
ECHA InfoCard100.022.050 Edit this at Wikidata
Chemical and physical data
FormulaC13H26N2O4
Molar mass274.361 g·mol−1
3D model (JSmol)
  • Interactive image
  • CCCCNC(=O)OCC(C)(CCC)COC(=O)N
  • InChI=1S/C13H26N2O4/c1-4-6-8-15-12(17)19-10-13(3,7-5-2)9-18-11(14)16/h4-10H2,1-3H3,(H2,14,16)(H,15,17) ☒N
  • Key:PRBORDFJHHAISJ-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

As the trade name Tybatran (Robins), it was formerly available in capsules of 125, 250, and 350 mg, taken 3 or 4 times a day for a total daily dosage of 750 mg to 2 g. The plasma half-life of the drug is three hours. At high doses in combination with phenothiazines, it could produce convulsions.[3]

References edit

  1. ^ Index Nominum 2000: International Drug Directory. Taylor & Francis. January 2000. p. 1077. ISBN 978-3-88763-075-1.
  2. ^ Segelman FH, Kelton E, Terzi RM, Kucharczyk N, Sofia RD (June 1985). "The comparative potency of phenobarbital and five 1,3-propanediol dicarbamates for hepatic cytochrome P450 induction in rats". Research Communications in Chemical Pathology and Pharmacology. 48 (3): 467–70. PMID 4023427.
  3. ^ American Medical Association Dept of Drugs (1977). AMA Drug Evaluations (3rd ed.). Littleton, Mass.: Pub. Sciences Group. p. 406. ISBN 978-0-88416-175-2. OCLC 1024170745.