Tycho Brahe (1546–1601) was an influential Danish astronomer.

Tycho Brahe may also refer to:

• Tycho Brahe (Martian crater)
• Tycho Brahe Planetarium, a planetarium in Copenhagen, Denmark
• HEAT 1X Tycho Brahe, the first amateur, suborbital crewed spacecraft
• Tycho Brahé, a 1993 album by Lightwave
• Jerry Holkins or Tycho Brahe, writer of Penny Arcade
• MF Tycho Brahe, a Danish train and car ferry