UGT2B17 Knowpia

UGT2B17
Identifiers
Aliases	UGT2B17, BMND12, UDPGT2B17, UDP glucuronosyltransferase family 2 member B17
External IDs	OMIM: 601903 MGI: 1919023 HomoloGene: 68144 GeneCards: UGT2B17
Gene location (Human)
Chr.	Chromosome 4 (human)
End	68,576,413 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	87,074,389 bp
RNA expression pattern
	Top expressed in
	duodenum; ; appendix; ; jejunal mucosa; ; rectum; ; right lobe of liver; ; pancreatic epithelial cell; ; bone marrow cells; ; gallbladder; ; corpus epididymis; ; spleen;
	Top expressed in
	left lobe of liver; ; right ventricle; ; sexually immature organism; ; stria vascularis; ; carotid body; ; jejunum; ; digastric muscle; ; duodenum; ; extraocular muscle; ; pancreas;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	glycosyltransferase activity; transferase activity; glucuronosyltransferase activity; retinoic acid binding; hexosyltransferase activity; UDP-glycosyltransferase activity;
Cellular component	integral component of membrane; organelle membrane; endoplasmic reticulum membrane; membrane; intracellular membrane-bounded organelle; endoplasmic reticulum;
Biological process	steroid metabolic process; metabolism; cellular glucuronidation;
	Sources:Amigo / QuickGO
Orthologs
	7367
	71773
	ENSG00000197888
	ENSMUSG00000035836
	O75795
	Q8R084
	NM_001077
	NM_152811
	NP_001068
	NP_690024
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-glucuronosyltransferase 2B17 is an enzyme that in humans is encoded by the UGT2B17 gene.^[5]^[6]

UGT2B17 belongs to the family of UDP-glucuronosyltransferases (UGTs; EC 2.4.1.17), enzymes that catalyze the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a variety of substrates, including steroid hormones.[supplied by OMIM]^[6] It also metabolizes 3-hydroxycotinine, which is minor nicotine metabolite^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000197888 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi:10.1074/jbc.271.37.22855. PMID 8798464.
^ ^a ^b "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".
^ Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

Further reading edit

Chung LW, Coffey DS (1978). "Androgen glucuronide. II. Differences in its formation by human normal and benign hyperplastic prostates". Investigative Urology. 15 (5): 385–8. PMID 76619.
Moghissi E, Ablan F, Horton R (1984). "Origin of plasma androstanediol glucuronide in men". J. Clin. Endocrinol. Metab. 59 (3): 417–21. doi:10.1210/jcem-59-3-417. PMID 6746859.
Beaulieu M, Lévesque E, Tchernof A, et al. (1997). "Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme". DNA Cell Biol. 16 (10): 1143–54. doi:10.1089/dna.1997.16.1143. PMID 9364925.
Collier AC, Ganley NA, Tingle MD, et al. (2002). "UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term". Biochem. Pharmacol. 63 (3): 409–19. doi:10.1016/S0006-2952(01)00890-5. PMID 11853692.
Chouinard S, Pelletier G, Bélanger A, Barbier O (2005). "Cellular specific expression of the androgen-conjugating enzymes UGT2B15 and UGT2B17 in the human prostate epithelium". Endocr. Res. 30 (4): 717–25. doi:10.1081/ERC-200044014. PMID 15666817. S2CID 10971899.
Lazarus P, Zheng Y, Aaron Runkle E, et al. (2006). "Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes". Pharmacogenet. Genomics. 15 (11): 769–78. doi:10.1097/01.fpc.0000175596.52443.ef. PMID 16220109. S2CID 10171438.
Jakobsson J, Ekström L, Inotsume N, et al. (2006). "Large differences in testosterone excretion in Korean and Swedish men are strongly associated with a UDP-glucuronosyl transferase 2B17 polymorphism". J. Clin. Endocrinol. Metab. 91 (2): 687–93. doi:10.1210/jc.2005-1643. PMID 16332934.
Park J, Chen L, Ratnashinge L, et al. (2006). "Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men". Cancer Epidemiol. Biomarkers Prev. 15 (8): 1473–8. doi:10.1158/1055-9965.EPI-06-0141. PMID 16896035.
Gallagher CJ, Muscat JE, Hicks AN, et al. (2007). "The UDP-glucuronosyltransferase 2B17 gene deletion polymorphism: sex-specific association with urinary 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronidation phenotype and risk for lung cancer". Cancer Epidemiol. Biomarkers Prev. 16 (4): 823–8. doi:10.1158/1055-9965.EPI-06-0823. PMID 17416778.
Park JY, Tanner JP, Sellers TA, et al. (2007). "Association between polymorphisms in HSD3B1 and UGT2B17 and prostate cancer risk". Urology. 70 (2): 374–9. doi:10.1016/j.urology.2007.03.001. PMID 17826523.
Chouinard S, Barbier O, Bélanger A (2008). "UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells". J. Biol. Chem. 282 (46): 33466–74. doi:10.1074/jbc.M703370200. PMID 17848572.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000197888 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000035836 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8798464-5] Beaulieu M, Levesque E, Hum DW, Belanger A (Nov 1996). "Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids". J Biol Chem. 271 (37): 22855–62. doi:10.1074/jbc.271.37.22855. PMID 8798464.

[entrez-6] "Entrez Gene: UGT2B17 UDP glucuronosyltransferase 2 family, polypeptide B17".

[pmid20876810-7] Chen G, Giambrone NE, Dluzen DF, Muscat JE, Berg A, Gallagher CJ, Lazarus P (October 2010). "Glucuronidation genotypes and nicotine metabolic phenotypes: importance of functional UGT2B10 and UGT2B17 polymorphisms". Cancer Research. 70 (19): 7543–52. doi:10.1158/0008-5472.CAN-09-4582. PMC 2998997. PMID 20876810.

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Summary

References edit

Further reading edit