The first USS Persistent (PYc-48) was a submarine chaser of the United States Navy.

History
United States
Launched	1931
Acquired	13 August 1940
Commissioned	16 October 1940
Decommissioned	27 September 1944
Stricken	14 October 1944
General characteristics
Displacement	110 tons
Length	120 ft (37 m)
Beam	22 ft (6.7 m)
Draught	6 ft 6 in (1.98 m)
Speed	12 kts
Armament	4 mg., 2 dct.

Persistent, built as Onwego in 1931, was purchased from the estate of Mr. G. L. Bourne, New York, 13 August 1940; renamed PC–456, 13 September; converted at the New York Navy Yard; and commissioned 16 October 1940.

Assigned to the 15th Naval District, PC–456 arrived in the Panama Canal Zone 13 November 1940.

Renamed and reclassified Persistent (PYc–48), 16 June 1943, she patrolled in and off the Canal Zone until the summer of 1944 when she sailed for Philadelphia, Pennsylvania and deactivation. Arriving 31 August, she decommissioned 27 September and was struck from the Navy List 14 October.