Voacamine, also known under the older names voacanginine and vocamine, is a naturally occurring dimeric indole alkaloid of the secologanin type, found in a number of plants, including Voacanga africana and Tabernaemontana divaricata. It is approved for use as an antimalarial drug in several African countries.[1] Voacamine exhibits cannabinoid CB1 receptor antagonistic activity.[2]
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ECHA InfoCard | 100.020.139 |
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Formula | C43H52N4O5 |
Molar mass | 704.912 g·mol−1 |
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There is considerable confusion about the absolute stereochemical configuration of voacamine and the originally published absolute structure had to be later revised.[3][4] It has an ibogaine unit joined with vobasine unit.
Voacamine can cause hypertension in high dose.[5]