Wertheim may refer to:

• Wertheim (surname)
• Wertheim (company), a company that manufactures vacuum cleaners
• Wertheim (department store), a chain of German department stores
• Wertheim & Co., an investment firm
• Wertheim am Main, Baden-Württemberg, Germany
• Wertheim National Wildlife Refuge, a protected wetlands on Long Island, New York
• Wertheim Piano, an Australian brand of piano
• Wertheim-Meigs operation, a surgical procedure for the treatment of cervical cancer