The William H. Nichols Medal is awarded annually for original research in chemistry. Nominees must have made a "significant and original contribution in any field of chemistry" during the five years preceding the presentation date. The medallist receives a gold medal, a bronze replica and a cash award. The award was established in 1902 by the New York Section of the American Chemical Society (ACS) through a gift from chemist and businessman William H. Nichols. It was the first award to be approved by the ACS. The medal was first awarded in 1903.