Born near Fishkill, New York, Van Wyck attended the public schools and Fishkill Academy. He engaged in agricultural pursuits.

Van Wyck was elected as a Democratic-Republican to the 17th and 18th United States Congresses, holding office from December 3, 1821, to March 3, 1825. He was Chairman of the Committee on Expenditures in the Post Office Department (18th Congress).

He removed to Sudley, Virginia, and engaged in planting. He returned to Dutchess County, New York, and died in Fishkill. He was buried at the Dutch Reformed Churchyard.

• United States Congress. "William W. Van Wyck (id: V000068)". Biographical Directory of the United States Congress.