Crusio and his collaborators found that neuroanatomical variations in the mouse hippocampus, in particular the sizes of their intra- and infrapyramidal mossy fibers (IIPMF) correlated with learning performance.[11] Together with Herbert Schwegler and Hans-Peter Lipp, Crusio showed that an inverse correlation, that is, animals with larger IIPMF learn better, could be found for spatial learning in a radial arm maze task.[12][13][14] Taken together, Crusio and collaborators think that it is highly likely that this correlation is causal,[15] although this is not universally accepted.[16]
Mouse model of depressionedit
When mice are exposed to unpredictable chronic mild stress (UCMS), they start exhibiting symptoms reminiscent of major depressive disorder in humans.[17] As it had been suggested that deficits in hippocampal neurogenesis might underlie depression,[18] Crusio and collaborators undertook a series of experiments investigating changes in behavior and neurogenesis in mice that had undergone UCMS. They showed dramatic changes in levels of aggression,[19]anxiety,[20][21] depressive-like behaviors,[20] and learning,[22] with a concomitant drop in neurogenesis.[22] However, the results were strain- and sex-specific and there did not appear to be a clear-cut correlation between the different changes, so that they finally concluded that although their data do not disprove the idea that deficits in hippocampal neurogenesis solely underlie the behavioral impairments observed in human psychiatric disorders such as depression, they do not provide support for this hypothesis either.[22]
Mouse model of autismedit
More recently, Crusio has been investigating the possibility that Fmr1knockout mice might perhaps be used as a model for autism. This idea is based on the fact that patients suffering from the Fragile X syndrome, caused by a deficiency of the FMR1 gene often show autistic symptoms. A good mouse model for the Fragile X syndrome is available in the form of mice in which the Fmr1 gene (the mouse homologue of the human FMR1 gene) has been invalidated.[23] A review of the findings obtained with these mice in many different laboratories did indeed indicate that these animals display autistic-like symptoms,[24] especially changes in social behavior, a key symptom of autism.[25][26]
According to Google Scholar, Crusio's works have been cited over 10,000 times and he has an h-index of 46.[57] Some significant papers are:
Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (2007). "A quantitative-genetic analysis of hippocampal variation in the mouse". Journal of Neurogenetics. 21 (4, Special Retrospective Issue: The Origins of Neurogenetics): 197–208. doi:10.1080/01677060701715827. PMID 18161583. S2CID 7334116. Original publication: Crusio, W. E.; Genthner-Grimm, G.; Schwegler, H. (July 1986). "A quantitative-genetic analysis of hippocampal variation in the mouse". Journal of Neurogenetics. 3 (4): 203–214. doi:10.3109/01677068609106850. PMID 3746523.
Crusio, W. E.; Schwegler, H.; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution". Brain Research. 425 (1): 182–185. doi:10.1016/0006-8993(87)90498-7. PMID 3427419. S2CID 39198617.
Crusio, W. E.; Schwegler, H.; van Abeelen, J. H. F. (February 1989). "Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis". Behavioural Brain Research. 32 (1): 81–88. doi:10.1016/S0166-4328(89)80075-0. PMID 2930637. S2CID 42291976.
Crusio W. E. (November 2001). "Genetic dissection of mouse exploratory behaviour". Behavioural Brain Research. 125 (1–2): 127–132. doi:10.1016/S0166-4328(01)00280-7. PMID 11682103. S2CID 28031277.
Crusio, W. E.; Goldowitz, D.; Holmes, A.; Wolfer, D. (February 2009). "Standards for the publication of mouse mutant studies". Genes, Brain and Behavior. 8 (1): 1–4. doi:10.1111/j.1601-183X.2008.00438.x. PMID 18778401. S2CID 205853147.
Referencesedit
^ ab"Wim E. Crusio Curriculum Vitae" (PDF). Wim E. Crusio Blog. February 2016. Archived from the original (PDF) on 7 November 2017. Retrieved 15 August 2018.
^Brünner, Gerhard (1987). "Crusio, Wim: Die Gattung Anubias (Araceae)". Für Ihre Bücherei. Aquarien Magazin (in German). 21 (7).
^Klix, Wolf-Dieter (2009). "Protokoll der Mitgliederversammlung 2009 des Arbeitskreises Wasserpflanzen in Dresden". Aqua Planta (in German). 34 (4): 150–151. Archived from the original on 7 October 2010. Retrieved 22 August 2010. Announcement of re-issue on CD of 1987 German edition of Anubias revision
^Crusio, WE (1984). Olfaction and behavioral responses to novelty in mice: A quantitative-genetic analysis. Meppel: Krips Repro. pp. viii+146+78. Archived from the original on 14 August 2016. Retrieved 31 July 2016.
^ abc"Curriculum Vitae Wim E. Crusio". Archived from the original on 30 January 2017. Retrieved 15 August 2018.
^"Publications by Humboldt Research Fellows from abroad in 2005: Biosciences, Life Sciences". Archived from the original on 27 September 2011. Retrieved 11 August 2009.
^"CNIC UMR5228 – Equipe 3 – Neurogénétique comportementale" (in French). Archived from the original on 30 October 2007. Retrieved 15 August 2009.
^Deris, Yves. "Nouvel arrivant à l'INB, aujourd'hui : Wim CRUSIO" (in French). Institut des Neurosciences de Bordeaux. Archived from the original on 17 July 2009. Retrieved 23 August 2009.
^"Crusio Wim". The Aquitaine Institute for Cognitive and Integrative Neuroscience. Archived from the original on 21 October 2014. Retrieved 29 December 2012.
^Crusio, W. E.; Schwegler, H; Lipp, H. P. (November 1987). "Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution". Brain Research. 425 (1): 182–185. doi:10.1016/0006-8993(87)90498-7. PMID 3427419. S2CID 39198617.
^Schwegler, H; Crusio, W. E.; Brust, I (1990). "Hippocampal mossy fibers and radial-maze learning in the mouse: a correlation with spatial working memory but not with non-spatial reference memory". Neuroscience. 34 (2): 293–298. doi:10.1016/0306-4522(90)90139-U. PMID 2333144. S2CID 9557091.
^Crawley, Jacqueline (2007). What's Wrong with My Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice. John Wiley & Sons. p. 138. ISBN 9780470119044. Archived from the original on 10 May 2016. Retrieved 8 February 2015.
^Crusio, W. E.; Schwegler, H (April 2005). "Learning spatial orientation tasks in the radial-maze and structural variation in the hippocampus in inbred mice". Behavioral and Brain Functions. 1 (3): 3. doi:10.1186/1744-9081-1-3. PMC1143776. PMID 15916698.
^Willner P (December 1997). "Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation". Psychopharmacology. 134 (4): 319–329. doi:10.1007/s002130050456. PMID 9452163. S2CID 40941720. Archived from the original on 30 April 1999. Retrieved 15 August 2009.
^Kempermann, G; Kronenberg, G (September 2003). "Depressed new neurons--adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression". Biological Psychiatry. 54 (5): 499–503. doi:10.1016/S0006-3223(03)00319-6. PMID 12946878. S2CID 26823096.
^Mineur, Y. S.; Prasol, D. J.; Belzung, C; Crusio, W. E. (September 2003). "Agonistic behavior and unpredictable chronic mild stress in mice" (PDF). Behavior Genetics. 33 (5): 513–519. doi:10.1023/A:1025770616068. PMID 14574128. S2CID 20402648. Retrieved 16 August 2009.[permanent dead link]
^ abMineur, Y. S.; Belzung, C; Crusio, W. E. (November 2006). "Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice". Behavioural Brain Research. 175 (1): 43–50. doi:10.1016/j.bbr.2006.07.029. PMID 17023061. S2CID 28014881.
^Wahlsten, Douglas (2010). Mouse Behavioral Testing: How to Use Mice in Behavioral Neuroscience. Academic Press. p. 166. ISBN 9780123756756. Archived from the original on 3 June 2016. Retrieved 6 February 2015.
^ abcMineur, Y. S.; Belzung, C; Crusio, W. E. (December 2007). "Functional implications of decreases in neurogenesis following chronic mild stress in mice". Neuroscience. 150 (2): 251–259. doi:10.1016/j.neuroscience.2007.09.045. PMID 17981399. S2CID 25560162.
^The Dutch-Belgian Fragile X Consortium (July 1994). "Fmr1 knockout mice: a model to study fragile X mental retardation". Cell. 78 (1): 23–33. doi:10.1016/0092-8674(94)90569-X. PMID 8033209. S2CID 29674883.
^Bernardet, M; Crusio, W. E. (2006). "Fmr1 KO mice as a possible model of autistic features". The Scientific World Journal. 6: 1164–1176. doi:10.1100/tsw.2006.220. PMC5917219. PMID 16998604.
^Mineur, Y. S.; Huynh, L. X.; Crusio, W. E. (March 2006). "Social behavior deficits in the Fmr1 mutant mouse". Behavioural Brain Research. 168 (1): 172–175. doi:10.1016/j.bbr.2005.11.004. PMID 16343653. S2CID 45731129.
^Spencer, C. M.; Alekseyenko, O; Serysheva, E; Yuva-Paylor, L. A.; Paylor, R (October 2005). "Altered anxiety-related and social behaviors in the Fmr1 knockout mouse model of fragile X syndrome". Genes, Brain and Behavior. 4 (7): 420–430. doi:10.1111/j.1601-183X.2005.00123.x. PMID 16176388. S2CID 9094269.
^Pagel, Mark (7 May 2004). "The order in a billion sequences". Times Higher Education. Archived from the original on 3 April 2012. Retrieved 9 July 2010.
^Crusio, W. E.; Goldowitz, D; Holmes, A; Wolfer, D (February 2009). "Standards for the publication of mouse mutant studies". Genes, Brain and Behavior. 8 (1): 1–4. doi:10.1111/j.1601-183X.2008.00438.x. PMID 18778401. S2CID 205853147.
^"Preparing your manuscript – Research – Criteria". Behavioral and Brain Functions. BioMed Central. Archived from the original on 3 June 2021. Retrieved 5 May 2020.
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^Crusio, Wim E. (September 1996). Crusio WE (ed.). "Special issue: The neurobehavioral genetics of aggression". Behavior Genetics. 26 (5): 459–504. doi:10.1007/BF02359749. PMID 8917943. S2CID 31579336. Archived from the original on 25 August 2017. Retrieved 14 August 2009.
^Crusio WE, ed. (September 1998). "Special issue: The genetic dissection of brain-behaviour relationships: An introduction to neurobehavioural genetics". Behavioural Brain Research. 95 (1): 1–142. doi:10.1016/S0166-4328(97)00203-9. S2CID 208791454. Archived from the original on 13 March 2013. Retrieved 14 August 2009.
^Gerlai RT (August 2001). Gerlai RT, Crusio WE (eds.). "Special issue: Bridging the gap from gene to behavior: Recombinant DNA techniques merge with behavioral neurobiology". Physiology and Behavior. 73 (5): 671–886. doi:10.1016/S0031-9384(01)00583-2. S2CID 54311109. Archived from the original on 24 September 2015. Retrieved 14 August 2009.
^Crusio WE, Routtenberg A (February 2001). Routtenberg A, Crusio WE (eds.). "Special Issue: Gene Targeting and Hippocampal Function". Hippocampus. 12 (1): 2–3. doi:10.1002/hipo.10001. PMID 11918284. S2CID 37535269. Archived from the original on 22 October 2012. Retrieved 14 August 2009.
^Belzung C, Crusio WE, Gerlai RT (January 2002). Belzung C, Crusio WE, Gerlai RT (eds.). "Special issue: Behavioral neurogenetics, the genetic dissection of brain and behavior". Brain Research Bulletin. 57 (1): 1–131. doi:10.1016/S0361-9230(01)00629-3. PMID 11827730. S2CID 9742148. Archived from the original on 24 September 2015. Retrieved 14 August 2009.
^Crusio, WE; Gerlai, RT (1999). Handbook of Molecular-Genetic Techniques for Brain and Behavior Research. Amsterdam: Elsevier. pp. xxvii+965. ISBN 978-0-444-50239-1.
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