YM-31636 is a potent and selective 5-HT₃ agonist.^[1] Systemic administration of YM-31636 increased the number of fecal pellets in rats, and improves colonic motility. It also increases colonic secretions, but not to the point of inducing diarrhea. In addition, it did not reduce the visceral pain threshold, or increase the intensity of visceral pain.^[2] These properties indicate that it could be a useful treatment for constipation.

YM-31636

Names
IUPAC name 2-(1H-imidazol-4-ylmethyl)-8H-indeno[1,2-d]thiazole
Identifiers
CAS Number	159081-22-8
3D model (JSmol)	Interactive image
ChemSpider	8083000
MeSH	C419869
PubChem CID	9907348
UNII	K9K8W6KEH2 Y
CompTox Dashboard (EPA)	DTXSID60432686
InChI InChI=1S/C14H11N3S/c1-2-4-11-9(3-1)5-12-14(11)17-13(18-12)6-10-7-15-8-16-10/h1-4,7-8H,5-6H2,(H,15,16) Key: SWXJBBYBDXFMGG-UHFFFAOYSA-N InChI=1/C14H11N3S/c1-2-4-11-9(3-1)5-12-14(11)17-13(18-12)6-10-7-15-8-16-10/h1-4,7-8H,5-6H2,(H,15,16) Key: SWXJBBYBDXFMGG-UHFFFAOYAP
SMILES n2c4c1ccccc1Cc4sc2Cc3c[nH]cn3
Properties
Chemical formula	C14H11N3S
Molar mass	253.32 g mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references