Yugandhar is a deadly and daredevil gangster. A special Interpol officer David is assigned to work with SP Jagannath. In spite of being on Interpol's most wanted list, Yugandhar remains elusive to the police. He kills one of his gang members Ramesh when he finds out that he is an informer of the police. His fiancée Kamini tries to avenge his death, but Yugandhar kills her also. Thereafter, Ramesh's sister Jaya takes judo and karate lessons in order to take revenge and she enters Yugandhar's gang. Once the Police get an opportunity to nab Yugandhar, the police finally succeed. Unfortunately, Yugandhar dies, which Jagannath only knows and he secretly buries Yugandhar's body, ensuring that people believe he may still be alive; Jagannath while returning after the funeral of Yugandhar, to his fortune encounters Vijay, who resembles Yugandhar. Jagannath hatches a plan to replace Yugandhar with Vijay so he can arrest the rest of the gang. Vijay is a street dancer who adopts two orphan kids and looks after them affectionately. Jagannath requests Vijay to go in place of Yugandhar after assuring him that he will take care of the kids. Vijay agrees. In fact, the kids' father Ram Singh is in jail. Ram Singh used to work in a circus company. He has an extraordinary talent for opening any type of locker. Once Shankar, one of the gang members, offers Ram Singh to open a bank safe. In the beginning, Ram Singh refuses, but he is compelled to do so when his wife is in serious condition. Unfortunately, he was caught by Jagannath, in that attack Ram Singh lost a limb and his wife died in hospital.

Meanwhile, Jagannath sends Vijay into the gang as a person who has lost his memory. Ram Singh, just released from jail, begins his mission against Jagannath and his search for his children. Eventually, like Vijay, learns more and more about Yugandhar and announces to his colleagues that he got back his memory. Vijay manages to replace the red diary which contains entire details of the gang and plans to give it to Jagannath. Jaya goes after him, but Vijay survives the attack and explains that he is Vijay. Jaya apologizes to Vijay and they fall in love. Vijay informs Jaganadham about a celebration that all the big smugglers and gangsters of the country are attending. When Jagannath is about to start, Ram Singh obstructs his way, but cannot do so as he learns that his children are with Jagannath. Jaganadham tells him that he will inform regarding them his return. But things take a drastic turn when the police raid the celebrations, Vijay's only witness to his true identity, Jagannath, is shot dead, and Vijay is arrested because the police think that he is Yugandhar. The diary that Vijay had handed over to Jagannath, which is his last hope, is stolen by Ram Singh. However, he escapes from the police and he begins to fight for himself and tries to prove his innocence. Jaya agrees to help him. Meanwhile, the gang kidnaps Ram Singh's children to take Vijay into their hold. Ram Singh blackmails the gang as he possesses the dairy. In that process, he discovers that Interpol officer David is the original gang leader who also murdered Jagannath. Ram Singh goes to negotiations with David when the police come there and Ram Singh is kept in a room where his children are present, Ram Singh takes the children and runs away. At the same time, Vijay arrives, both of them mistake each other as the enemy of the children and a quarrel arises between them. After knowing the truth from the children, both of them join hands, along with Jaya, to catch the entire gang and Vijay proves that he is not Yugandhar.

• N. T. Rama Rao as Yugandhar and Vijay
• Jayasudha as Jaya
• Satyanarayana as Ram Singh
• Jaggayya as SP Jagannath
• Prabhakar Reddy as David/Bhanoji
• Kanta Rao as Inspector Varma
• Thyagaraju as Shankar
• Prasad Babu as Ramesh
• Jayamalini as Kamini
• Sheela as Anita
• Chalapathi Rao as Chalapathi
• Prabhakar as Gang member who fights with Vijay

Music was composed by Ilaiyaraaja.^[2] The song "Vorrabbaa Vesukunnaa Killii" is based on "Khaike Pan Banaraswala" from Don.^[3] The song "Naa Kosame" was used in the Telugu dubbed version of the 2023 Tamil film Leo.

In 2009, a second Telugu remake of the Hindi film Don, titled Billa, was released.^[4] Jayasudha played a guest role, different from the role she played in Yugandhar.^{[citation needed]}

• Yugandhar at IMDb