Zachariah Poulson (1761—1844) was an American editor and publisher.

Poulson was born in Philadelphia in 1761. In 1800, he purchased Claypoole's American Daily Advertiser, the successor to America's first daily newspaper, the Pennsylvania Packet. He was state printer for some years, and the publisher of Poulson's Town and Country Almanac, 1789-1801. He also published Proud's History of Pennsylvania, 1797-98. He was a member of several literary and charitable associations, and connected with the Library Company of Philadelphia for 58 years.