Zakir Hussain (Urdu: ذاکِر حسین) may refer to:

• Zakir Hussain (actor), Bollywood actor
• Zakir Hussain (field hockey) (1934–2019), Pakistani field hockey player
• Zakir Hussain (Haryana politician), Indian politician
• Zakir Hussain (Hyderabad cricketer) (born 1964), Indian cricketer
• Zakir Hussain (musician) (born 1951), Indian classical tabla player
• Zakir Hussain (Pakistani cricketer), Pakistani cricketer who played for Pakistan Air Force