Ziyad Al-Aly is an American physician and clinical epidemiologist who is currently Director of the Clinical Epidemiology Center and Chief of the Research and Development at the Veterans Affairs St. Louis Health Care System.[1][2][3] He is also a clinical epidemiologist at Washington University in St. Louis.[2] He has led multiple studies on long covid and its sequelae.[4]
Early lifeedit
Al-Aly was born in Tripoli, Lebanon to teachers.[5] He grew up during the Lebanese civil war which dominated Lebanon from 1975 to 1990,[5] emigrating to the United States in 2000.
Al-Aly's research work has been cited more than a 100,000 times and he has an h-index of more than 79 according to Google Scholar.[7]
Long COVID researchedit
Al-Aly led work which provided the first systematic characterization of the post-acute sequelae of SARS-CoV-2 infection.[8] He subsequently led work which characterized the increased risks of cardiovascular disease,[9] neurologic disorders,[10] mental health disorders,[11] gastrointestinal disorders,[12] diabetes,[13] dyslipidemia,[14] and kidney disease[15] following SARS-CoV-2 infection. His lab also produced evidence characterizing the effects of COVID-19 vaccines on long COVID[16] and the health consequences of repeated infections with SARS-CoV-2.[17]
In 2024, Al-Aly testified before the U.S. Senate Health, Education, Labor and Pensions Committee as an expert witness on Long Covid. He called for the establishment of an NIH institute to address Long Covid and Infection-Associated Chronic Conditions (IACCs) — also called post-acute infection syndrome — with a funding of at least $1 billion per year.[18]
Pharmacoepidemiologyedit
Including work characterizing the adverse health effect of proton pump inhibitors and comparative effectiveness of antihyperglycemic medications. His work also included examining the effectiveness of COVID-19 antivirals including paxlovid (nirmatrelvir/ritonavir) and molnupiravir on acute COVID-19 outcomes[19][20] and long COVID.[21][22]
Environmental epidemiology researchedit
Including work which evaluated the effect of air pollution on kidney health,[23] diabetes,[24] and early mortality.[25]
Honors and awardsedit
In 2023, Al-Aly was awarded the U.S. Department of Veterans Affairs Secretary's Award — the highest VA award — for outstanding contributions to research.
Referencesedit
^"Repeat coronavirus infections can still be dangerous, study suggests". The Washington Post. Retrieved 11 November 2022.
^Xie, Yan; Al-Aly, Ziyad (2022-05-01). "Risks and burdens of incident diabetes in long COVID: a cohort study". The Lancet Diabetes & Endocrinology. 10 (5): 311–321. doi:10.1016/S2213-8587(22)00044-4. ISSN 2213-8587. PMC8937253. PMID 35325624.
^Xu, Evan; Xie, Yan; Al-Aly, Ziyad (2023-02-01). "Risks and burdens of incident dyslipidaemia in long COVID: a cohort study". The Lancet Diabetes & Endocrinology. 11 (2): 120–128. doi:10.1016/S2213-8587(22)00355-2. ISSN 2213-8587. PMC9873268. PMID 36623520.
^Bowe, Benjamin; Xie, Yan; Xu, Evan; Al-Aly, Ziyad (November 2021). "Kidney Outcomes in Long COVID". Journal of the American Society of Nephrology. 32 (11): 2851–2862. doi:10.1681/ASN.2021060734. ISSN 1046-6673. PMC8806085. PMID 34470828. S2CID 237389462.
^"Testimony of Ziyad Al-Aly, M.D., Clinical Epidemiologist, Washington University in Saint Louis, Saint Louis, MO Before United States Senate Committee on Health, Education, Labor and Pensions" (PDF). U.S. Senate Committee on Health, Education, Labor and Pensions. January 18, 2024. Archived from the original (PDF) on 2024-01-18.
^Xie, Yan; Bowe, Benjamin; Al-Aly, Ziyad (2023-04-11). "Nirmatrelvir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records". BMJ. 381: e073312. doi:10.1136/bmj-2022-073312. ISSN 1756-1833. PMC10086514. PMID 37041016.
^Xie, Yan; Bowe, Benjamin; Al-Aly, Ziyad (2023-03-07). "Molnupiravir and risk of hospital admission or death in adults with covid-19: emulation of a randomized target trial using electronic health records". BMJ. 380: e072705. doi:10.1136/bmj-2022-072705. ISSN 1756-1833. PMC9989554. PMID 36882199.
^Xie, Yan; Choi, Taeyoung; Al-Aly, Ziyad (2023-06-01). "Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition". JAMA Internal Medicine. 183 (6): 554–564. doi:10.1001/jamainternmed.2023.0743. ISSN 2168-6106. PMC10037200. PMID 36951829.
^Xie, Yan; Choi, Taeyoung; Al-Aly, Ziyad (2023-04-25). "Molnupiravir and risk of post-acute sequelae of covid-19: cohort study". BMJ. 381: e074572. doi:10.1136/bmj-2022-074572. ISSN 1756-1833. PMC10126525. PMID 37161995.
^Bowe, Benjamin; Xie, Yan; Li, Tingting; Yan, Yan; Xian, Hong; Al-Aly, Ziyad (January 2018). "Particulate Matter Air Pollution and the Risk of Incident CKD and Progression to ESRD". Journal of the American Society of Nephrology. 29 (1): 218–230. doi:10.1681/ASN.2017030253. ISSN 1046-6673. PMC5748906. PMID 28935655.
^Bowe, Benjamin; Xie, Yan; Li, Tingting; Yan, Yan; Xian, Hong; Al-Aly, Ziyad (July 2018). "The 2016 global and national burden of diabetes mellitus attributable to PM 2·5 air pollution". The Lancet Planetary Health. 2 (7): e301–e312. doi:10.1016/s2542-5196(18)30140-2. ISSN 2542-5196. PMID 30074893.
^Bowe, Benjamin; Xie, Yan; Yan, Yan; Al-Aly, Ziyad (2019-11-20). "Burden of Cause-Specific Mortality Associated With PM 2.5 Air Pollution in the United States". JAMA Network Open. 2 (11): e1915834. doi:10.1001/jamanetworkopen.2019.15834. ISSN 2574-3805. PMC6902821. PMID 31747037.
External linksedit
Publications
A 2023 profile on Ziyad Al-Aly published by Washington University in St. Louis