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Zolantidine

Summary

Zolantidine is a brain-penetrating selective histamine H2 receptor (HRH2) antagonist developed by Smith, Kline & French, with the research code of SK&F 95282. It is a benzothiazole derivative with a 30-fold higher potency for H2 receptors than other peripheral and central receptors.[1]

Zolantidine
Clinical data
ATC code
  • None
Identifiers
  • N-[3-[3-(piperidin-1-ylmethyl)phenoxy]propyl]-1,3-benzothiazol-2-amine
CAS Number
  • 104076-38-2
PubChem CID
  • 91769
ChemSpider
  • 82866
UNII
  • M1108XAY01
ChEMBL
  • ChEMBL419296
CompTox Dashboard (EPA)
  • DTXSID6048460 Edit this at Wikidata
Chemical and physical data
FormulaC22H27N3OS
Molar mass381.54 g·mol−1
3D model (JSmol)
  • Interactive image
  • n1c4ccccc4sc1NCCCOc2cc(ccc2)CN3CCCCC3
  • InChI=1S/C22H27N3OS/c1-4-13-25(14-5-1)17-18-8-6-9-19(16-18)26-15-7-12-23-22-24-20-10-2-3-11-21(20)27-22/h2-3,6,8-11,16H,1,4-5,7,12-15,17H2,(H,23,24)
  • Key:KUBONGDXTUOOLM-UHFFFAOYSA-N

References edit

  1. ^ Calcutt CR, Ganellin CR, Griffiths R, Leigh BK, Maguire JP, Mitchell RC, et al. (January 1988). "Zolantidine (SK&F 95282) is a potent selective brain-penetrating histamine H2-receptor antagonist". British Journal of Pharmacology. 93 (1): 69–78. doi:10.1111/j.1476-5381.1988.tb11406.x. PMC 1853786. PMID 2894879.