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Exatecan is a water soluble topoisomerase I inhibitor, with an IC50 of 2.2 μM (0.975 μg/mL)
2018-09-17 18:51
Exatecan is a potent topoisomerase I inhibitor, with an IC50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the
proli..
NVP-HDM201 (HDM201) is a potent and highly specific MDM-2
2018-09-16 21:58
NVP-HDM201 disrupts both human and murine TP53- MDM2 interactions, with nanomolar cellular IC50 values, blocking TP53 degradation.NVP-HDM201..
IPI549 is a potent and selective PI3Kγ Inhibitor with an IC50 of 16 nM
2018-09-16 18:07
IPI-549 inhibits PI3Kγ with IC50 of 16 nM, with >100-fold selectivity over other lipid and protein kinases (PI3Kα IC50=3.2 μM, PI3Kβ IC50..
(+)-JQ-1 is a BET bromodomain inhibitor, with IC50 of 77 nM/33 nM for the first
2018-09-13 23:10
(+)-JQ1represents a potent, highly specific and Kac competitive
inhibitor for the BET family of bromodomains. (+)-JQ1 (100 nM, 48 h)
pro..
ML RR-S2 CDA ammonium salt is an inducer of STING (stimulator of interferon genes)
2018-09-13 18:28
ML RR-S2 CDA shows enhanced type I IFN production over CDA in THP-1
human monocytes. In contrast, the dithio, mixed-linkage cyclic
dinuc..
Merimepodib is a novel noncompetitive inhibitor
2018-09-13 00:10
VX-497 has antiproliferative effect on lymphoid and keratinocyte cells.
The antiproliferative effect of VX-497 in cells is reversed within..
JNJ-632 is a hepatitis B virus (HBV) capsid assembly modulator (CAM)
2018-09-12 23:18
JNJ-632 is a capsid assembly modulator inhibiting hepatitis B virus
(HBV). JNJ-632 inhibits HBV DNA HepG2.2.15 and HBV DNA HepG2.117 with ..
Adefovir Dipivoxil works by blocking reverse transcriptase
2018-09-12 22:11
AB-423 is an inhibitor of HBV capsid assembly. AB-423 shows inhibitory
effect on rcDNA production in AML12-HBV10 and HepDE19 cells with EC..
Squalamine(MSI-1256) is an aminosterol compound with potent broad spectrum antiviral activity
2018-09-12 18:18
Squalamine(MSI-1256) is an aminosterol compound with potent broad
spectrum antiviral activity.
IC50 value:
Target:
in vitro: squalamine..
Entecavir monohydrate (SQ 34676; BMS 200475) is a potent
2018-09-11 21:50
BMS-200475 has a EC50 of 3.75 nM against HBV. It is
incorporated into the protein primer of HBV and subsequently inhibits
the priming st..
Tenofovir Disoproxil Fumarate is a nucleotide reverse transcriptase inhibitor to treat HIV
2018-09-11 18:24
Tenofovir shows cytotoxic effects on cell viability in HK-2 cells, with IC50
values of 9.21 and 2.77 μM at 48 and 72 h in MTT assay, respe..
BAY 41-4109 is a potent inhibitor of human hepatitis B virus (HBV) with an IC50 of 53 nM
2018-09-10 22:51
BAY 41-4109is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio..
Pirodavir is a potent, broad-spectrum picornavirus inhibitor
2018-09-10 19:26
Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes.
P..
GP(33-41) is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus
2018-09-10 18:39
GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1
epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db..
ST-193 is a potent broad-spectrum arenavirus inhibitor
2018-09-10 00:50
ST-193 is a potent broad-spectrum arenavirus inhibitor; inhibits Guanarito, Junin, Lassa and Machupo virus with IC50 values of 0.44, 0.62, 1..