The wing was first organized as the 4750th Training Wing at Yuma County Airport in 1953, when ADC's gunnery training program expanded from a squadron sized unit to a wing. The wing conducted interceptor aircraft training for ADC at Yuma (later Vincent Air Force Base) until moving to MacDill in 1959. Shortly afterward, the wing was discontinued and the ADC training program transferred to another wing.
The wing was established at Yuma County Airport in September 1953 as the 4750th Training Wing (Air Defense) when the Air Defense Command fighter gunnery training program there expanded. The gunnery program had been established at Yuma when the 4750th Air Base Squadron (Gunnery Training) was organized in 1951. The squadron had expanded to group strength in 1952 and was assigned to the wing when the wing was organized The wing specialized in air-to-air weapons training and testing for Air Defense Command. The wing also acted as the USAF Host organization for Vincent Air Force Base.
Beginning in 1955, the wing hosted the interceptor phase of the worldwide fighter aircraft gunnery and weapons meet (later called William Tell), which was designed to provide information to evaluate combat readiness, tactical capabilities of aircraft and weapons and effectiveness of interceptor techniques. The meet moved to Tyndall Air Force Base, Florida in 1958.
In 1958, the wing conducted research testing for the use of special weapons by fighter aircraft. The wing moved from Arizona to Florida in 1959 and was discontinued a year later, with most of its functions being assumed by the 4756th Air Defense Wing.
Designated as the 4750th Training Wing (Air Defense) and organized on 1 September 1953
Redesignated 4750th Air Defense Wing (Weapons) on 1 September 1954
Cornett, Lloyd H; Johnson, Mildred W (1980). A Handbook of Aerospace Defense Organization, 1946–1980(PDF). Peterson AFB, CO: Office of History, Aerospace Defense Center.
"AF Pamphlet 900-2, Unit Decorations, Awards and Campaign Participation Credits" (PDF). Washington, DC: Department of the Air Force. 15 June 1971. Retrieved August 11, 2016.
Grant, C.L., (1961) The Development of Continental Air Defense to 1 September 1954, USAF Historical Study No. 126
Leonard, Barry (2009). History of Strategic Air and Ballistic Missile Defense(PDF). Vol I. 1945-1955. Fort McNair, DC: Center for Military History. ISBN 978-1-4379-2131-1. |volume= has extra text (help)
Leonard, Barry (2009). History of Strategic Air and Ballistic Missile Defense(PDF). Vol II, 1955–1972. Fort McNair, DC: Center for Military History. ISBN 978-1-4379-2131-1. |volume= has extra text (help)
Winkler, David F.; Webster, Julie L (1997). Searching the skies : the legacy of the United States Cold War Defense Radar Program(PDF). Champaign, IL: US Army Construction Engineering Research Laboratories. LCCN97020912.
"Marine Corps Air Station Yuma: The Corps' Premier Aviation Training Facility". United States Marine Corps. Retrieved 2 January 2014.
"Information for Vincent AFB, Yuma, AZ". Radomes.org. Retrieved 2 January 2014.