Brain-specific angiogenesis inhibitor 3 is a protein that in humans is encoded by the BAI3 gene.[5][6]
ADGRB3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | ADGRB3, BAI3, adhesion G protein-coupled receptor B3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602684 MGI: 2441837 HomoloGene: 1289 GeneCards: ADGRB3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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BAI1, a p53-target gene, encodes brain-specific angiogenesis inhibitor, a seven-span transmembrane protein and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities and may also play a role in angiogenesis.[6] The BAI3 receptor has also been found to regulate dendrite morphogenesis, arborization growth and branching in cultured neurons.[7]
The adhesion GPCR BaI3 is an orphan receptor that has a long N-terminus consisting of one cub domain, five BaI Thrombospondin type 1 repeats, and one hormone binding domain.[8] BaI3 is expressed in neural tissues of the central nervous system. BaI3 has been shown to have a high affinity for C1q proteins. C1q added to hippocampal neurons expressing BaI3 resulted in a decrease in the number of synapses.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.