CD109 Knowpia

CD109
Identifiers
Aliases	CD109, CPAMD7, p180, r150, CD109 molecule
External IDs	OMIM: 608859 MGI: 2445221 HomoloGene: 25183 GeneCards: CD109
Gene location (Human)
Chr.	Chromosome 6 (human)
End	73,828,316 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	78,623,535 bp
RNA expression pattern
	Top expressed in
	tibia; ; synovial membrane; ; vulva; ; nipple; ; gums; ; Achilles tendon; ; stromal cell of endometrium; ; human penis; ; synovial joint; ; visceral pleura;
	Top expressed in
	calvaria; ; spermatid; ; body of femur; ; skin of back; ; ankle; ; cornea; ; lip; ; epidermis; ; belly cord; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	peptidase inhibitor activity; endopeptidase inhibitor activity; transforming growth factor beta binding; serine-type endopeptidase inhibitor activity;
Cellular component	cell surface; anchored component of membrane; membrane; extracellular region; extracellular space; plasma membrane; platelet alpha granule membrane;
Biological process	hair follicle development; negative regulation of protein phosphorylation; regulation of keratinocyte differentiation; osteoclast fusion; negative regulation of wound healing; negative regulation of peptidase activity; negative regulation of transforming growth factor beta receptor signaling pathway; negative regulation of keratinocyte proliferation; negative regulation of endopeptidase activity; platelet degranulation; C-terminal protein lipidation;
	Sources:Amigo / QuickGO
Orthologs
	135228
	235505
	ENSG00000156535
	ENSMUSG00000046186
	Q6YHK3
	Q8R422
	NM_001159587; NM_001159588; NM_133493
	NM_153098
	NP_001153059; NP_001153060; NP_598000
	NP_694738
	Wikidata
View/Edit Human	View/Edit Mouse

CD109 (Cluster of Differentiation 109) is a human gene.^[5]

CD109 is a GPI-linked cell surface antigen expressed by CD34+ acute myeloid leukemia cell lines, T-cell lines, activated T lymphoblasts, endothelial cells, and activated platelets (Lin et al., 2002). In addition, the platelet-specific Gov antigen system (HPA15),^[6] implicated in refractoriness to platelet transfusion, neonatal alloimmune thrombocytopenia, and posttransfusion purpura, is carried by CD109 (Kelton et al., 1990; Lin et al., 2002).[supplied by OMIM]^[5]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000156535 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000046186 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: CD109 CD109 molecule".
^ "IPD - HPA Sequence Database| EBI".

Further reading edit

Lucas GF, Metcalfe P (2000). "Platelet and granulocyte glycoprotein polymorphisms". Transfusion Medicine (Oxford, England). 10 (3): 157–74. doi:10.1046/j.1365-3148.2000.00250.x. PMID 10972910. S2CID 43709043.
Sutherland DR, Yeo E, Ryan A, et al. (1991). "Identification of a cell-surface antigen associated with activated T lymphoblasts and activated platelets". Blood. 77 (1): 84–93. doi:10.1182/blood.V77.1.84.84. PMID 1984805.
Kelton JG, Smith JW, Horsewood P, et al. (1990). "Gova/b alloantigen system on human platelets". Blood. 75 (11): 2172–6. doi:10.1182/blood.V75.11.2172.2172. PMID 2346781.
Lin M, Sutherland DR, Horsfall W, et al. (2002). "Cell surface antigen CD109 is a novel member of the alpha(2) macroglobulin/C3, C4, C5 family of thioester-containing proteins". Blood. 99 (5): 1683–91. doi:10.1182/blood.V99.5.1683. PMID 11861284.
Schuh AC, Watkins NA, Nguyen Q, et al. (2002). "A tyrosine703serine polymorphism of CD109 defines the Gov platelet alloantigens". Blood. 99 (5): 1692–8. doi:10.1182/blood.V99.5.1692. PMID 11861285.
Giesert C, Marxer A, Sutherland DR, et al. (2003). "Antibody W7C5 defines a CD109 epitope expressed on CD34+ and CD34- hematopoietic and mesenchymal stem cell subsets". Ann. N. Y. Acad. Sci. 996 (1): 227–30. Bibcode:2003NYASA.996..227G. doi:10.1111/j.1749-6632.2003.tb03250.x. PMID 12799300. S2CID 24117857.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Solomon KR, Sharma P, Chan M, et al. (2004). "CD109 represents a novel branch of the alpha2-macroglobulin/complement gene family". Gene. 327 (2): 171–83. doi:10.1016/j.gene.2003.11.025. PMID 14980714.
Zhang JM, Hashimoto M, Kawai K, et al. (2005). "CD109 expression in squamous cell carcinoma of the uterine cervix". Pathol. Int. 55 (4): 165–9. doi:10.1111/j.1440-1827.2005.01807.x. PMID 15826242. S2CID 24693926.
Lewandrowski U, Moebius J, Walter U, Sickmann A (2006). "Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach". Mol. Cell. Proteomics. 5 (2): 226–33. doi:10.1074/mcp.M500324-MCP200. PMID 16263699.
Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human Plasma N-Glycoproteome Analysis by Immunoaffinity Subtraction, Hydrazide Chemistry, and Mass Spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
Finnson KW, Tam BY, Liu K, et al. (2006). "Identification of CD109 as part of the TGF-beta receptor system in human keratinocytes". FASEB J. 20 (9): 1525–7. doi:10.1096/fj.05-5229fje. PMID 16754747. S2CID 30768709.
Sjöblom T, Jones S, Wood LD, et al. (2006). "The consensus coding sequences of human breast and colorectal cancers". Science. 314 (5797): 268–74. Bibcode:2006Sci...314..268S. doi:10.1126/science.1133427. PMID 16959974. S2CID 10805017.
Hasegawa M, Hagiwara S, Sato T, et al. (2007). "CD109, a new marker for myoepithelial cells of mammary, salivary, and lacrimal glands and prostate basal cells". Pathol. Int. 57 (5): 245–50. doi:10.1111/j.1440-1827.2007.02097.x. PMID 17493171. S2CID 23930267.

External links edit

CD109+Antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Human CD109 genome location and CD109 gene details page in the UCSC Genome Browser.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000156535 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000046186 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CD109 CD109 molecule".

[6] "IPD - HPA Sequence Database| EBI".

[5]

[1]

[2]

[3]

[4]

[6]

Summary

See also edit

References edit

Further reading edit

External links edit