Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.[5][6]
CD37 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | CD37, GP52-40, TSPAN26, CD37 molecule | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility.[7][8][9][10] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms.[6] CD37 controls both humoral[11][12] and cellular immune responses.[13][14][15] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma,[16] and patients with CD37-negative lymphomas have a worse clinical outcome.[17]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.