Cell division control protein 6 homolog is a protein that in humans is encoded by the CDC6 gene.[5][6]
CDC6 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | CDC6, CDC18L, HsCDC18, Hscell division cycle 6, MGORS5 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602627 MGI: 1345150 HomoloGene: 68172 GeneCards: CDC6 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in the cell nucleus during cell cycle phase G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during the cell cycle is regulated through its phosphorylation by cyclin-dependent kinases. Transcription of this protein was reported to be regulated in response to mitogenic signals through a transcriptional control mechanism involving E2F proteins.[7]
CDC6 has been shown to interact with ORC1L,[6][8] ORC2L,[8][9] Cyclin A2,[6][10] PPP2R3B,[11] MCM3,[9][12] PPP2R3A,[13] MCM7[8][12] and PSKH1.[10]