CELSR2 Knowpia

CELSR2
Identifiers
Aliases	CELSR2, CDHF10, EGFL2, Flamingo1, MEGF3, ADGRC2, cadherin EGF LAG seven-pass G-type receptor 2
External IDs	OMIM: 604265 MGI: 1858235 HomoloGene: 1078 GeneCards: CELSR2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	109,275,751 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	108,323,383 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; prefrontal cortex; ; hippocampus proper; ; postcentral gyrus; ; Brodmann area 9; ; superior frontal gyrus; ; entorhinal cortex; ; Region I of hippocampus proper; ; right uterine tube; ; skin of abdomen;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; lip; ; subiculum; ; superior frontal gyrus; ; visual cortex; ; motor neuron; ; ascending aorta; ; extensor digitorum longus muscle; ; supraoptic nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; calcium ion binding; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; cytoplasm;
Biological process	homophilic cell adhesion via plasma membrane adhesion molecules; regulation of transcription, DNA-templated; cell surface receptor signaling pathway; multicellular organism development; regulation of cell-cell adhesion; Wnt signaling pathway, planar cell polarity pathway; G protein-coupled receptor signaling pathway; signal transduction; neural plate anterior/posterior regionalization; Wnt signaling pathway; cell adhesion; dendrite morphogenesis; cell-cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	1952
	53883
	ENSG00000143126
	ENSMUSG00000068740
	Q9HCU4
	Q9R0M0
	NM_001408
	NM_001004177; NM_017392
	NP_001399
	NP_001004177; NP_059088
	Wikidata
View/Edit Human	View/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 2 is a protein that in humans is encoded by the CELSR2 gene.^[5]^[6]

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143126 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068740 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics. 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
^ ^a ^b "Entrez Gene: CELSR2 cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila)".