CENPK Knowpia

CENPK
Identifiers
Aliases	CENPK, AF5alpha, CENP-K, P33, Solt, FKSG14, centromere protein K
External IDs	OMIM: 611502 MGI: 1926210 HomoloGene: 11035 GeneCards: CENPK
Gene location (Human)
Chr.	Chromosome 5 (human)
End	65,563,168 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	104,388,900 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; ganglionic eminence; ; thymus; ; rectum; ; appendix; ; bone marrow; ; stromal cell of endometrium; ; spongy bone; ; lymph node;
	Top expressed in
	medial ganglionic eminence; ; primitive streak; ; vas deferens; ; spermatid; ; otic placode; ; Paneth cell; ; maxillary prominence; ; condyle; ; renal corpuscle; ; fossa;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; nucleus; nucleoplasm; chromosome, centromeric region; chromosome; kinetochore;
Biological process	CENP-A containing chromatin assembly; kinetochore assembly; mitotic sister chromatid segregation;
	Sources:Amigo / QuickGO
Orthologs
	64105
	60411
	ENSG00000123219
	ENSMUSG00000021714
	Q9BS16
	Q9ESN5
	NM_001267038; NM_022145; NM_001349367; NM_001349368; NM_001349369
	NM_021790; NM_181061; NM_001377093; NM_001377094; NM_001377095
	NP_001253967; NP_071428; NP_001336296; NP_001336297; NP_001336298
	NP_068562; NP_851406; NP_001364022; NP_001364023; NP_001364024
	Wikidata
View/Edit Human	View/Edit Mouse

Centromere protein K is a protein that in humans is encoded by the CENPK gene.^[5]^[6]

Interactions edit

CENPK has been shown to interact with SOX6.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123219 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021714 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID 8950979.
^ "Entrez Gene: CENPK centromere protein K".
^ Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

External links edit

Human CENPK genome location and CENPK gene details page in the UCSC Genome Browser.

Further reading edit

Izuta H, Ikeno M, Suzuki N, Tomonaga T, Nozaki N, Obuse C, Kisu Y, Goshima N, Nomura F, Nomura N, Yoda K (Jun 2006). "Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells". Genes to Cells. 11 (6): 673–84. doi:10.1111/j.1365-2443.2006.00969.x. PMID 16716197. S2CID 45931410.
Okada M, Cheeseman IM, Hori T, Okawa K, McLeod IX, Yates JR, Desai A, Fukagawa T (May 2006). "The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres". Nature Cell Biology. 8 (5): 446–57. doi:10.1038/ncb1396. PMID 16622420. S2CID 26974412.
Foltz DR, Jansen LE, Black BE, Bailey AO, Yates JR, Cleveland DW (May 2006). "The human CENP-A centromeric nucleosome-associated complex". Nature Cell Biology. 8 (5): 458–69. doi:10.1038/ncb1397. PMID 16622419. S2CID 205286556.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (Feb 2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes to Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096. S2CID 21813024.
Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000123219 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021714 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8950979-5] Taki T, Hayashi Y, Taniwaki M, Seto M, Ueda R, Hanada R, Suzukawa K, Yokota J, Morishita K (Nov 1996). "Fusion of the MLL gene with two different genes, AF-6 and AF-5alpha, by a complex translocation involving chromosomes 5, 6, 8 and 11 in infant leukemia". Oncogene. 13 (10): 2121–30. PMID 8950979.

[entrez-6] "Entrez Gene: CENPK centromere protein K".

[pmid10996314-7] Yamashita A, Ito M, Takamatsu N, Shiba T (Sep 2000). "Characterization of Solt, a novel SoxLZ/Sox6 binding protein expressed in adult mouse testis". FEBS Letters. 481 (2): 147–51. doi:10.1016/S0014-5793(00)01987-6. PMID 10996314. S2CID 20831354.

[5]

[6]

[1]

[2]

[3]

[4]

[7]

Summary

Interactions edit

References edit

External links edit

Further reading edit