Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.[5][6][7]
COX7A2 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL, cytochrome c oxidase subunit 7A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 123996 MGI: 1316715 HomoloGene: 36082 GeneCards: COX7A2 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.
This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues.
In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.[7]