DCP2 Knowpia

DCP2
Identifiers
Aliases	DCP2, NUDT20, decapping mRNA 2
External IDs	OMIM: 609844 MGI: 1917890 HomoloGene: 13968 GeneCards: DCP2
Gene location (Human)
Chr.	Chromosome 5 (human)
End	113,022,195 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	44,558,036 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; spongy bone; ; sperm; ; parietal pleura; ; placenta; ; monocyte; ; bone marrow; ; visceral pleura; ; endothelial cell;
	Top expressed in
	hand; ; otolith organ; ; utricle; ; primitive streak; ; superior cervical ganglion; ; vas deferens; ; condyle; ; abdominal wall; ; trigeminal ganglion; ; renal corpuscle;
	More reference expression data
	n/a
Gene ontology
Molecular function	m7G(5')pppN diphosphatase activity; manganese ion binding; metal ion binding; protein binding; exoribonuclease activity, producing 5'-phosphomonoesters; RNA binding; hydrolase activity; 5'-3' exoribonuclease activity; telomerase RNA binding;
Cellular component	cytoplasm; RISC complex; cytosol; P-body; nucleoplasm; cell junction; nucleus; cytoplasmic ribonucleoprotein granule;
Biological process	mRNA catabolic process; regulation of mRNA stability; deadenylation-dependent decapping of nuclear-transcribed mRNA; exonucleolytic catabolism of deadenylated mRNA; histone mRNA catabolic process; RNA phosphodiester bond hydrolysis, exonucleolytic; nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; negative regulation of telomere maintenance via telomerase; regulation of telomerase RNA localization to Cajal body;
	Sources:Amigo / QuickGO
Orthologs
	167227
	70640
	ENSG00000172795
	ENSMUSG00000024472
	Q8IU60
	Q9CYC6
	NM_001242377; NM_152624
	NM_027490
	NP_001229306; NP_689837
	NP_081766
	Wikidata
View/Edit Human	View/Edit Mouse

mRNA-decapping enzyme 2 is a protein that in humans is encoded by the DCP2 gene.^[5]^[6]^[7]

DCP2 is a key component of an mRNA-decapping complex required for removal of the 5-prime cap from mRNA prior to its degradation from the 5-prime end (Fenger-Gron et al., 2005).[supplied by OMIM]^[7]

Interactions edit

DCP2 has been shown to interact with DCP1A^[8] and UPF1.^[6]^[9]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172795 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000024472 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (October 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme". Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 12663–12668. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.
^ ^a ^b Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
^ ^a ^b "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".
^ Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.
^ Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–687. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.

Further reading edit

Ueno K, Kumagai T, Kijima T, Kishimoto T, Hosoe S (January 1998). "Cloning and tissue expression of cDNAs from chromosome 5q21-22 which is frequently deleted in advanced lung cancer". Human Genetics. 102 (1): 63–68. doi:10.1007/s004390050655. PMID 9490301. S2CID 36201527.
van Dijk E, Cougot N, Meyer S, Babajko S, Wahle E, Séraphin B (December 2002). "Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures". The EMBO Journal. 21 (24): 6915–6924. doi:10.1093/emboj/cdf678. PMC 139098. PMID 12486012.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (December 2002). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci". RNA. 8 (12): 1489–1501. doi:10.1017/S1355838202021726. PMC 1370355. PMID 12515382.
Grzymski EC (June 2003). "Visualizing an mRNA destruction line". Nature Structural Biology. 10 (6): 416. doi:10.1038/nsb0603-416. PMID 12768200. S2CID 40900780.
Piccirillo C, Khanna R, Kiledjian M (September 2003). "Functional characterization of the mammalian mRNA decapping enzyme hDcp2". RNA. 9 (9): 1138–1147. doi:10.1261/rna.5690503. PMC 1370477. PMID 12923261.
Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–687. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.
Cougot N, Babajko S, Séraphin B (April 2004). "Cytoplasmic foci are sites of mRNA decay in human cells". The Journal of Cell Biology. 165 (1): 31–40. doi:10.1083/jcb.200309008. PMC 2172085. PMID 15067023.
Lehner B, Sanderson CM (July 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–1323. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.
Liu SW, Jiao X, Liu H, Gu M, Lima CD, Kiledjian M (September 2004). "Functional analysis of mRNA scavenger decapping enzymes". RNA. 10 (9): 1412–1422. doi:10.1261/rna.7660804. PMC 1370627. PMID 15273322.
Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R (July 2005). "MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies". Nature Cell Biology. 7 (7): 719–723. doi:10.1038/ncb1274. PMC 1855297. PMID 15937477.
Fenger-Grøn M, Fillman C, Norrild B, Lykke-Andersen J (December 2005). "Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping". Molecular Cell. 20 (6): 905–915. doi:10.1016/j.molcel.2005.10.031. PMID 16364915.
Wichroski MJ, Robb GB, Rana TM (May 2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies". PLOS Pathogens. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMC 1458959. PMID 16699599.
Chu CY, Rana TM (July 2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54". PLOS Biology. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMC 1475773. PMID 16756390.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172795 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000024472 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12218187-5] Wang Z, Jiao X, Carr-Schmid A, Kiledjian M (October 2002). "The hDcp2 protein is a mammalian mRNA decapping enzyme". Proceedings of the National Academy of Sciences of the United States of America. 99 (20): 12663–12668. Bibcode:2002PNAS...9912663W. doi:10.1073/pnas.192445599. PMC 130517. PMID 12218187.

[pmid12417715-6] Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.

[entrez-7] "Entrez Gene: DCP2 DCP2 decapping enzyme homolog (S. cerevisiae)".

[autogenerated1-8] Lykke-Andersen J (December 2002). "Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay". Molecular and Cellular Biology. 22 (23): 8114–8121. doi:10.1128/MCB.22.23.8114-8121.2002. PMC 134073. PMID 12417715.

[pmid14527413-9] Lejeune F, Li X, Maquat LE (September 2003). "Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities". Molecular Cell. 12 (3): 675–687. doi:10.1016/S1097-2765(03)00349-6. PMID 14527413.

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Summary

Interactions edit

References edit

Further reading edit