DLX1 Knowpia

DLX1
Identifiers
Aliases	DLX1, Dlx, Dlx-1, distal-less homeobox 1
External IDs	OMIM: 600029 MGI: 94901 HomoloGene: 22558 GeneCards: DLX1
Gene location (Human)
Chr.	Chromosome 2 (human)
End	172,089,677 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	71,364,325 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; ganglionic eminence; ; prefrontal cortex; ; Brodmann area 23; ; dorsolateral prefrontal cortex; ; Brodmann area 9; ; amygdala; ; hypothalamus; ; putamen;
	Top expressed in
	medial ganglionic eminence; ; olfactory bulb; ; nasolacrimal duct; ; otic placode; ; fossa; ; paraventricular nucleus of hypothalamus; ; maxillary prominence; ; lateral hypothalamus; ; hair follicle; ; condyle;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; sequence-specific DNA binding; RNA polymerase II transcription regulatory region sequence-specific DNA binding; chromatin binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding; DNA-binding transcription factor activity;
Cellular component	nucleus;
Biological process	negative regulation of neuron apoptotic process; cerebral cortex GABAergic interneuron differentiation; proximal/distal pattern formation; cell differentiation; regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; embryonic skeletal system development; multicellular organism development; odontogenesis of dentin-containing tooth; cerebral cortex GABAergic interneuron fate commitment; negative regulation of oligodendrocyte differentiation; forebrain neuron differentiation; hippocampus development; subpallium development; negative regulation of Notch signaling pathway; positive regulation of cell differentiation; negative regulation of photoreceptor cell differentiation; positive regulation of amacrine cell differentiation; negative regulation of transcription by RNA polymerase II; negative regulation of BMP signaling pathway; positive regulation of transcription by RNA polymerase II; cellular response to transforming growth factor beta stimulus; cellular response to BMP stimulus; negative regulation of cellular response to transforming growth factor beta stimulus; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	1745
	13390
	ENSG00000144355
	ENSMUSG00000041911
	P56177
	Q64317
	NM_001038493; NM_178120
	NM_010053
	NP_001033582; NP_835221
	NP_034183
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein DLX-1 is a protein that in humans is encoded by the DLX1 gene.^[5]^[6]

Function edit

This gene encodes a member of a homeobox transcription factor gene family similar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-β superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000144355 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041911 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.
^ ^a ^b "Entrez Gene: DLX1 distal-less homeobox 1".

Further reading edit

Letinic K, Zoncu R, Rakic P (2002). "Origin of GABAergic neurons in the human neocortex". Nature. 417 (6889): 645–9. Bibcode:2002Natur.417..645L. doi:10.1038/nature00779. PMID 12050665. S2CID 4349070.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Chiba S, Takeshita K, Imai Y, et al. (2004). "Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells". Proc. Natl. Acad. Sci. U.S.A. 100 (26): 15577–82. doi:10.1073/pnas.2536757100. PMC 307610. PMID 14671321.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Zhou QP, Le TN, Qiu X, et al. (2004). "Identification of a direct Dlx homeodomain target in the developing mouse forebrain and retina by optimization of chromatin immunoprecipitation". Nucleic Acids Res. 32 (3): 884–92. doi:10.1093/nar/gkh233. PMC 373381. PMID 14769946.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Hamilton SP, Woo JM, Carlson EJ, et al. (2006). "Analysis of four DLX homeobox genes in autistic probands". BMC Genet. 6: 52. doi:10.1186/1471-2156-6-52. PMC 1310613. PMID 16266434.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000144355 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041911 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7907794-5] Simeone A, Acampora D, Pannese M, D'Esposito M, Stornaiuolo A, Gulisano M, Mallamaci A, Kastury K, Druck T, Huebner K, et al. (Apr 1994). "Cloning and characterization of two members of the vertebrate Dlx gene family". Proc Natl Acad Sci U S A. 91 (6): 2250–4. Bibcode:1994PNAS...91.2250S. doi:10.1073/pnas.91.6.2250. PMC 43348. PMID 7907794.

[entrez-6] "Entrez Gene: DLX1 distal-less homeobox 1".

[5]

[6]

[1]

[2]

[3]

[4]

Summary

Function edit

References edit

Further reading edit