DNAH9 Knowpia

DNAH9
Identifiers
Aliases	DNAH9, DNAH17L, DNEL1, DYH9, Dnahc9, HL-20, HL20, dynein axonemal heavy chain 9, CILD40
External IDs	OMIM: 603330 MGI: 1289279 HomoloGene: 20357 GeneCards: DNAH9
Gene location (Human)
Chr.	Chromosome 17 (human)
End	11,969,748 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	66,059,377 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; bronchial epithelial cell; ; sperm; ; caudate nucleus; ; secondary oocyte; ; hypothalamus; ; nucleus accumbens; ; prefrontal cortex; ; amygdala; ; optic nerve;
	Top expressed in
	secondary oocyte; ; olfactory epithelium; ; vestibular labyrinth; ; visual cortex; ; right lung lobe; ; spermatid; ; hippocampus proper; ; pituitary gland; ; seminiferous tubule; ; superior frontal gyrus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	microtubule motor activity; nucleotide binding; ATPase activity; ATP binding; cytoskeletal motor activity; minus-end-directed microtubule motor activity; dynein light chain binding; dynein intermediate chain binding; dynein light intermediate chain binding;
Cellular component	cytoplasm; axoneme; cell projection; cilium; microtubule; cytoskeleton; dynein complex; motile cilium; 9+2 motile cilium; distal portion of axoneme;
Biological process	microtubule-based movement; cell projection organization; cilium movement;
	Sources:Amigo / QuickGO
Orthologs
	1770
	237806
	ENSG00000007174
	ENSMUSG00000056752
	Q9NYC9
	n/a
	NM_001372; NM_004662
	NM_001099633
	NP_001363; NP_004653
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Dynein heavy chain 9, axonemal is a protein that in humans is encoded by the DNAH9 gene.^[5]^[6]^[7]

This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000007174 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000056752 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (Feb 1997). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.
^ Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE (Mar 2001). "Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia". Genomics. 72 (1): 21–33. doi:10.1006/geno.2000.6462. hdl:2123/16163. PMID 11247663.
^ ^a ^b "Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9".

Further reading edit

Milisav I, Jones MH, Affara NA (1996). "Characterization of a novel human dynein-related gene that is specifically expressed in testis". Mamm. Genome. 7 (9): 667–72. doi:10.1007/s003359900202. PMID 8703119. S2CID 30004271.
Nagase T; Ishikawa K; Nakajima D; et al. (1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
Bartoloni L; Blouin J; Sainsbury AJ; et al. (1999). "Assignment of the human dynein heavy chain gene DNAH17L to human chromosome 17p12 by in situ hybridization and radiation hybrid mapping". Cytogenet. Cell Genet. 84 (3–4): 188–9. doi:10.1159/000015254. PMID 10393427. S2CID 1495548.
Reed W; Carson JL; Moats-Staats BM; et al. (2001). "Characterization of an axonemal dynein heavy chain expressed early in airway epithelial ciliogenesis". Am. J. Respir. Cell Mol. Biol. 23 (6): 734–41. CiteSeerX 10.1.1.321.874. doi:10.1165/ajrcmb.23.6.4045. PMID 11104725.
Maiti AK; Mattéi MG; Jorissen M; et al. (2001). "Identification, tissue specific expression, and chromosomal localisation of several human dynein heavy chain genes". Eur. J. Hum. Genet. 8 (12): 923–32. doi:10.1038/sj.ejhg.5200555. PMID 11175280.
Carson JL; Reed W; Lucier T; et al. (2002). "Axonemal dynein expression in human fetal tracheal epithelium". Am. J. Physiol. Lung Cell Mol. Physiol. 282 (3): L421–30. doi:10.1152/ajplung.00147.2001. PMID 11839535. S2CID 23922796.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Horváth J; Fliegauf M; Olbrich H; et al. (2005). "Identification and analysis of axonemal dynein light chain 1 in primary ciliary dyskinesia patients". Am. J. Respir. Cell Mol. Biol. 33 (1): 41–7. doi:10.1165/rcmb.2004-0335OC. PMID 15845866. S2CID 19776274.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000007174 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000056752 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8812413-5] Vaughan KT, Mikami A, Paschal BM, Holzbaur EL, Hughes SM, Echeverri CJ, Moore KJ, Gilbert DJ, Copeland NG, Jenkins NA, Vallee RB (Feb 1997). "Multiple mouse chromosomal loci for dynein-based motility". Genomics. 36 (1): 29–38. doi:10.1006/geno.1996.0422. PMID 8812413.

[pmid11247663-6] Bartoloni L, Blouin JL, Maiti AK, Sainsbury A, Rossier C, Gehrig C, She JX, Marron MP, Lander ES, Meeks M, Chung E, Armengot M, Jorissen M, Scott HS, Delozier-Blanchet CD, Gardiner RM, Antonarakis SE (Mar 2001). "Axonemal beta heavy chain dynein DNAH9: cDNA sequence, genomic structure, and investigation of its role in primary ciliary dyskinesia". Genomics. 72 (1): 21–33. doi:10.1006/geno.2000.6462. hdl:2123/16163. PMID 11247663.

[entrez-7] "Entrez Gene: DNAH9 dynein, axonemal, heavy chain 9".

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[6]

[7]

[1]

[2]

[3]

[4]

Summary

References edit

Further reading edit