DUSP22 Knowpia

DUSP22
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WRM, 4WOH
Identifiers
Aliases	DUSP22, JKAP, JSP-1, JSP1, LMW-DSP2, LMWDSP2, MKP-x, MKPX, VHX, dual specificity phosphatase 22
External IDs	OMIM: 616778 MGI: 1915926 HomoloGene: 86039 GeneCards: DUSP22
Gene location (Human)
Chr.	Chromosome 6 (human)
End	351,355 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	30,895,214 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; hair follicle; ; visceral pleura; ; monocyte; ; parietal pleura; ; Brodmann area 23; ; tibia; ; endothelial cell; ; middle temporal gyrus; ; palpebral conjunctiva;
	Top expressed in
	lip; ; esophagus; ; spermatid; ; digastric muscle; ; cumulus cell; ; cornea; ; skeletal muscle tissue; ; thoracic diaphragm; ; extraocular muscle; ; temporal muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein tyrosine phosphatase activity; phosphatase activity; phosphoprotein phosphatase activity; hydrolase activity; protein tyrosine/serine/threonine phosphatase activity; non-membrane spanning protein tyrosine phosphatase activity; protein tyrosine kinase binding;
Cellular component	cytoplasm; nucleus; cytosol; plasma membrane; filamentous actin; leading edge of lamellipodium;
Biological process	multicellular organism development; negative regulation of T cell mediated immunity; protein dephosphorylation; peptidyl-tyrosine dephosphorylation; cell population proliferation; negative regulation of T cell activation; negative regulation of transcription by RNA polymerase II; transforming growth factor beta receptor signaling pathway; regulation of cell population proliferation; positive regulation of JNK cascade; negative regulation of T cell receptor signaling pathway; dephosphorylation; apoptotic process; negative regulation of cell migration; negative regulation of focal adhesion assembly; cellular response to epidermal growth factor stimulus; negative regulation of non-membrane spanning protein tyrosine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	56940
	105352
	ENSG00000112679
	ENSMUSG00000069255
	Q9NRW4
	Q99N11
	NM_001286555; NM_020185
	NM_001037955; NM_134068
	NP_001273484; NP_064570
	NP_001033044; NP_598829
	Wikidata
View/Edit Human	View/Edit Mouse

Dual specificity protein phosphatase 22 is an enzyme that in humans is encoded by the DUSP22 gene.^[5]^[6]^[7]

Interactions edit

DUSP22 has been shown to interact with MAPK1^[8] and MAPK8.^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112679 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069255 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Smith A, Price C, Cullen M, Muda M, King A, Ozanne B, Arkinstall S, Ashworth A (Sep 1997). "Chromosomal localization of three human dual specificity phosphatase genes (DUSP4, DUSP6, and DUSP7)". Genomics. 42 (3): 524–7. doi:10.1006/geno.1997.4756. PMID 9205128.
^ Shen Y, Luche R, Wei B, Gordon ML, Diltz CD, Tonks NK (Nov 2001). "Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1". Proc Natl Acad Sci U S A. 98 (24): 13613–8. Bibcode:2001PNAS...9813613S. doi:10.1073/pnas.231499098. PMC 61089. PMID 11717427.
^ "Entrez Gene: DUSP22 dual specificity phosphatase 22".
^ ^a ^b Aoyama, K; Nagata M; Oshima K; Matsuda T; Aoki N (Jul 2001). "Molecular cloning and characterization of a novel dual specificity phosphatase, LMW-DSP2, that lacks the cdc25 homology domain". J. Biol. Chem. 276 (29): 27575–83. doi:10.1074/jbc.M100408200. ISSN 0021-9258. PMC 3757226. PMID 11346645.