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DYNC1I1

Summary

Cytoplasmic dynein 1 intermediate chain 1 is a protein that in humans is encoded by the DYNC1I1 gene.[5][6][7]

DYNC1I1
Identifiers
AliasesDYNC1I1, dynein, cytoplasmic 1, intermediate chain 1, DNCI1, DNCIC1, dynein cytoplasmic 1 intermediate chain 1
External IDsOMIM: 603772 MGI: 107743 HomoloGene: 68398 GeneCards: DYNC1I1
Orthologs
SpeciesHumanMouse
Entrez

1780

13426

Ensembl

ENSG00000158560

ENSMUSG00000029757

UniProt

O14576

O88485

RefSeq (mRNA)

NM_001135556
NM_001135557
NM_001278421
NM_001278422
NM_004411

NM_001191023
NM_001191025
NM_001191026
NM_001191027
NM_010063

RefSeq (protein)

NP_001129028
NP_001129029
NP_001265350
NP_001265351
NP_004402

NP_001177952
NP_001177954
NP_001177955
NP_001177956
NP_034193

Location (UCSC)Chr 7: 95.77 – 96.11 MbChr 6: 5.73 – 6.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

In melanocytic cells DYNC1I1 gene expression may be regulated by MITF.[8]

Interactions edit

DYNC1I1 has been shown to interact with DYNLL1.[9]

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000158560 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029757 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Crackower MA, Sinasac DS, Xia J, Motoyama J, Prochazka M, Rommens JM, Scherer SW, Tsui LC (May 1999). "Cloning and characterization of two cytoplasmic dynein intermediate chain genes in mouse and human". Genomics. 55 (3): 257–67. doi:10.1006/geno.1998.5665. PMID 10049579.
  6. ^ Pfister KK, Fisher EM, Gibbons IR, Hays TS, Holzbaur EL, McIntosh JR, Porter ME, Schroer TA, Vaughan KT, Witman GB, King SM, Vallee RB (Nov 2005). "Cytoplasmic dynein nomenclature". J Cell Biol. 171 (3): 411–3. doi:10.1083/jcb.200508078. PMC 2171247. PMID 16260502.
  7. ^ "Entrez Gene: DYNC1I1 dynein, cytoplasmic 1, intermediate chain 1".
  8. ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971. S2CID 24698373.
  9. ^ Diefenbach, Russell J; Diefenbach Eve; Douglas Mark W; Cunningham Anthony L (Dec 2002). "The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23". Biochemistry. 41 (50). United States: 14906–15. doi:10.1021/bi026417u. ISSN 0006-2960. PMID 12475239.

Further reading edit

  • King SM, Dillman JF, Benashski SE, et al. (1997). "The mouse t-complex-encoded protein Tctex-1 is a light chain of brain cytoplasmic dynein". J. Biol. Chem. 271 (50): 32281–7. doi:10.1074/jbc.271.50.32281. PMID 8943288.
  • Lo KW, Naisbitt S, Fan JS, et al. (2001). "The 8-kDa dynein light chain binds to its targets via a conserved (K/R)XTQT motif". J. Biol. Chem. 276 (17): 14059–66. doi:10.1074/jbc.M010320200. PMID 11148209.
  • Horikawa I, Parker ES, Solomon GG, Barrett JC (2001). "Upregulation of the gene encoding a cytoplasmic dynein intermediate chain in senescent human cells". J. Cell. Biochem. 82 (3): 415–21. doi:10.1002/jcb.1169. PMID 11500918. S2CID 10899690.
  • Karki S, Ligon LA, DeSantis J, et al. (2002). "PLAC-24 is a cytoplasmic dynein-binding protein that is recruited to sites of cell-cell contact". Mol. Biol. Cell. 13 (5): 1722–34. doi:10.1091/mbc.02-02-0011. PMC 111139. PMID 12006665.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ligon LA, Tokito M, Finklestein JM, et al. (2004). "A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity". J. Biol. Chem. 279 (18): 19201–8. doi:10.1074/jbc.M313472200. PMID 14985359.
  • Villacé P, Marión RM, Ortín J (2004). "The composition of Staufen-containing RNA granules from human cells indicates their role in the regulated transport and translation of messenger RNAs". Nucleic Acids Res. 32 (8): 2411–20. doi:10.1093/nar/gkh552. PMC 419443. PMID 15121898.
  • Chuang JZ, Yeh TY, Bollati F, et al. (2005). "The dynein light chain Tctex-1 has a dynein-independent role in actin remodeling during neurite outgrowth". Dev. Cell. 9 (1): 75–86. doi:10.1016/j.devcel.2005.04.003. PMC 3857739. PMID 15992542.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.