Giesecke may refer to:

People:

• Heinz-Eberhard Giesecke (1913–1991), German historian
• Karl Ludwig Giesecke FRSE (1761–1833), German actor, librettist, polar explorer and mineralogist
• Markus Giesecke (born 1979), German futsal player from Regensburg

Businesses:

• Giesecke & Devrient (G&D), German company that prints banknotes and securities, smart cards, etc.
• Schelter & Giesecke Type Foundry, German type foundry & manufacturer of printing presses started in 1819 in Leipzig

Geography:

• Giesecke Glacier, a glacier in Avannaata municipality in northwestern Greenland
• Giesecke Isfjord, a fjord in Avannaata municipality in northwestern Greenland