HIST1H1T Knowpia

H1-6
Identifiers
Aliases	H1-6, H1FT, H1t, dJ221C16.2, H1.6, histone cluster 1, H1t, histone cluster 1 H1 family member t, HIST1H1T, H1.6 linker histone, cluster member
External IDs	OMIM: 142712 MGI: 1888530 HomoloGene: 3889 GeneCards: H1-6
Gene location (Human)
Chr.	Chromosome 6 (human)
End	26,108,135 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,880,708 bp
RNA expression pattern
	Top expressed in
	monocyte; ; corpus callosum; ; blood; ; testicle; ; islet of Langerhans; ; right lung; ; human musculoskeletal system; ; right lobe of liver; ; gastrocnemius muscle; ; thigh;
	Top expressed in
	spermatocyte; ; spermatid; ; pharynx; ; lesser wing of sphenoid bone; ; entorhinal cortex; ; secondary oocyte; ; extraocular muscle; ; trigeminal ganglion; ; upper arm; ; testicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; double-stranded DNA binding; protein binding; nucleosomal DNA binding;
Cellular component	nucleosome; nucleus; chromosome; condensed nuclear chromosome;
Biological process	multicellular organism development; nucleosome assembly; cell differentiation; spermatogenesis; regulation of transcription, DNA-templated; binding of sperm to zona pellucida; chromosome condensation; flagellated sperm motility; negative regulation of DNA recombination;
	Sources:Amigo / QuickGO
Orthologs
	3010
	107970
	ENSG00000187475
	ENSMUSG00000036211
	P22492
	Q07133
	NM_005323
	NM_010377
	NP_005314
	NP_034507
	Wikidata
View/Edit Human	View/Edit Mouse

Histone H1t is a protein that in humans is encoded by the HIST1H1T gene.^[5]^[6]^[7]

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000187475 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036211 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Koppel DA, Wolfe SA, Fogelfeld LA, Merchant PS, Prouty L, Grimes SR (Jun 1994). "Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6". J Cell Biochem. 54 (2): 219–30. doi:10.1002/jcb.240540210. PMID 8175896. S2CID 13648109.
^ Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.
^ ^a ^b "Entrez Gene: HIST1H1T histone cluster 1, H1t".

Further reading edit

Drabent B, Kardalinou E, Doenecke D (1991). "Structure and expression of the human gene encoding testicular H1 histone (H1t)". Gene. 103 (2): 263–8. doi:10.1016/0378-1119(91)90284-I. PMID 1889752.
Albig W, Drabent B, Kunz J, et al. (1993). "All known human H1 histone genes except the H1(0) gene are clustered on chromosome 6". Genomics. 16 (3): 649–54. doi:10.1006/geno.1993.1243. PMID 8325638.
Albig W, Kioschis P, Poustka A, et al. (1997). "Human histone gene organization: nonregular arrangement within a large cluster". Genomics. 40 (2): 314–22. doi:10.1006/geno.1996.4592. PMID 9119399.
Malanga M, Atorino L, Tramontano F, et al. (1998). "Poly(ADP-ribose) binding properties of histone H1 variants". Biochim. Biophys. Acta. 1399 (2–3): 154–60. doi:10.1016/s0167-4781(98)00110-9. PMID 9765591.
Steger K, Klonisch T, Gavenis K, et al. (1999). "Expression of mRNA and protein of nucleoproteins during human spermiogenesis". Mol. Hum. Reprod. 4 (10): 939–45. doi:10.1093/molehr/4.10.939. PMID 9809674.
Wellman SE, Song Y, Mamoon NM (1999). "Sequence preference of mouse H1(0) and H1t". Biochemistry. 38 (40): 13112–8. doi:10.1021/bi9914917. PMID 10529182.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000187475 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036211 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8175896-5] Koppel DA, Wolfe SA, Fogelfeld LA, Merchant PS, Prouty L, Grimes SR (Jun 1994). "Primate testicular histone H1t genes are highly conserved and the human H1t gene is located on chromosome 6". J Cell Biochem. 54 (2): 219–30. doi:10.1002/jcb.240540210. PMID 8175896. S2CID 13648109.

[pmid12408966-6] Marzluff WF, Gongidi P, Woods KR, Jin J, Maltais LJ (Oct 2002). "The human and mouse replication-dependent histone genes". Genomics. 80 (5): 487–98. doi:10.1016/S0888-7543(02)96850-3. PMID 12408966.

[entrez-7] "Entrez Gene: HIST1H1T histone cluster 1, H1t".

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[6]

[7]

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[2]

[3]

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Summary

References edit

Further reading edit