Homeobox protein Hox-A7 is a protein that in humans is encoded by the HOXA7 gene.[5][6][7]
HOXA7 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | HOXA7, ANTP, HOX1, HOX1.1, HOX1A, homeobox A7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 142950 MGI: 96179 HomoloGene: 56001 GeneCards: HOXA7 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.[7]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.