HOXC13 Knowpia

HOXC13
Identifiers
Aliases	HOXC13, ECTD9, HOX3, HOX3G, homeobox C13
External IDs	OMIM: 142976 MGI: 99560 HomoloGene: 7770 GeneCards: HOXC13
Gene location (Human)
Chr.	Chromosome 12 (human)
End	53,946,544 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	102,837,249 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; skin of abdomen; ; placenta; ; popliteal artery; ; breast; ; mammary gland; ; renal cortex; ; human musculoskeletal system; ; subcutaneous adipose tissue; ; urinary bladder;
	Top expressed in
	lip; ; hair follicle; ; filiform papilla; ; skin of back; ; skin of abdomen; ; morula; ; surface ectoderm; ; neural tube; ; placenta; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding; protein binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus;
Biological process	hair follicle development; multicellular organism development; nail development; regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; anterior/posterior pattern specification; tongue morphogenesis; positive regulation of transcription by RNA polymerase II; anatomical structure morphogenesis;
	Sources:Amigo / QuickGO
Orthologs
	3229
	15422
	ENSG00000123364
	ENSMUSG00000001655
	P31276
	P50207
	NM_017410
	NM_010464
	NP_059106
	NP_034594
	Wikidata
View/Edit Human	View/Edit Mouse

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.^[5]^[6]^[7]

Function edit

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene may play a role in the development of hair, nail, and filiform papilla.^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000123364 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000001655 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McAlpine PJ, Shows TB (Jul 1990). "Nomenclature for human homeobox genes". Genomics. 7 (3): 460. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
^ Scott MP (Nov 1992). "Vertebrate homeobox gene nomenclature". Cell. 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459. S2CID 13370372.
^ ^a ^b "Entrez Gene: HOXC13 homeobox C13".