Isoproscaline

Summary

Isoproscaline or 4-isopropoxy-3,5-dimethoxyphenethylamine is an analog of mescaline. It is closely related to proscaline and was first synthesized by David E. Nichols.[citation needed] It produces hallucinogenic, psychedelic, and entheogenic effects.

Isoproscaline
Names
Preferred IUPAC name
2-{3,5-Dimethoxy-4-[(propan-2-yl)oxy]phenyl}ethan-1-amine
Other names
2-(4-Isopropoxy-3,5-dimethoxyphenyl)ethanamine
Identifiers
  • 64778-72-9 checkY
3D model (JSmol)
  • Interactive image
ChEMBL
  • ChEMBL126203 checkY
ChemSpider
  • 10439597 checkY
  • 15102787
UNII
  • 7W67II88GC checkY
  • DTXSID70215088 Edit this at Wikidata
  • InChI=1S/C13H21NO3/c1-9(2)17-13-11(15-3)7-10(5-6-14)8-12(13)16-4/h7-9H,5-6,14H2,1-4H3 checkY
    Key: UBNHYNYMUORHAM-UHFFFAOYSA-N checkY
  • InChI=1/C13H21NO3/c1-9(2)17-13-11(15-3)7-10(5-6-14)8-12(13)16-4/h7-9H,5-6,14H2,1-4H3
    Key: UBNHYNYMUORHAM-UHFFFAOYAL
  • CC(C)Oc1c(cc(cc1OC)CCN)OC
Properties
C13H21NO3
Molar mass 239.31 g/mol
Melting point 163 to 164 °C (325 to 327 °F; 436 to 437 K) (hydrochloride)
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Chemistry edit

Isoproscaline is in a class of compounds commonly known as phenethylamines, and the full chemical name is 2-(4-isopropoxy-3,5-dimethoxyphenyl)ethanamine.

Effects edit

Little is known about the psychopharmacological effects of isoproscaline. In his book PiHKAL, Alexander Shulgin lists a psychedelic dosage as being 40–80 mg, with effects lasting 10–16 hours.[1]

Pharmacology edit

The mechanism that produces the hallucinogenic and entheogenic effects of isoproscaline is most likely to result from action as a 5-HT2A serotonin receptor agonist in the brain, a mechanism of action shared by all of the hallucinogenic tryptamines and phenethylamines.

Dangers edit

The toxicity of isoproscaline is not known.

Legality edit

Isoproscaline is unscheduled in the United States; however, because of its close similarity in structure and effects to mescaline, possession and sale of isoproscaline may be subject to prosecution under the Federal Analog Act.

In the UK, its highly likely that this compound would be covered by the "phenylethylamine amendment" to the misuse of drugs act likely rendering it a Class A controlled drug.

See also edit

References edit

  1. ^ Isoproscaline entry in PiHKAL