BREAKING NEWS
Cloud Server Hosting For Online Businesses
Inexpensive SEO Services
Benefits of Wanting to play Free Online Slot machines
KIFC1

Summary

Kinesin-like protein KIFC1 is a protein that in humans is encoded by the KIFC1 gene.[5][6]

KIFC1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesKIFC1, HSET, KNSL2, kinesin family member C1
External IDsOMIM: 603763 MGI: 2137414 HomoloGene: 83229 GeneCards: KIFC1
Orthologs
SpeciesHumanMouse
Entrez

3833

16580

Ensembl

ENSG00000233450
ENSG00000204197
ENSG00000237649
ENSG00000056678

ENSMUSG00000024301

UniProt

Q9BW19

Q9QWT9

RefSeq (mRNA)

NM_002263

NM_016761
NM_053173

RefSeq (protein)

NP_002254

NP_001182227

Location (UCSC)Chr 6: 33.39 – 33.41 MbChr 17: 27.14 – 27.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Function edit

The protein KifC1 is a member of kinesin-14 family. KifC1 consists of C-terminal motor domain, superhelical stalk and N-terminal tail domain. Tail and motor domains contain microtubule-binding sites. This kinesin moves towards the minus-end of microtubule and has an ability to slide or crosslink microtubules. KifC1 functions during mitotic spindle formation.

References edit

  1. ^ a b c ENSG00000204197, ENSG00000237649, ENSG00000056678 GRCh38: Ensembl release 89: ENSG00000233450, ENSG00000204197, ENSG00000237649, ENSG00000056678 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024301 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ando A, Kikuti YY, Kawata H, Okamoto N, Imai T, Eki T, Yokoyama K, Soeda E, Ikemura T, Abe K (Feb 1994). "Cloning of a new kinesin-related gene located at the centromeric end of the human MHC region". Immunogenetics. 39 (3): 194–200. doi:10.1007/bf00241260. PMID 8276466. S2CID 8880453.
  6. ^ "Entrez Gene: KIFC1 kinesin family member C1".

Further reading edit

  • Miki H, Setou M, Kaneshiro K, Hirokawa N (2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7004–7011. Bibcode:2001PNAS...98.7004M. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
  • Janitz K, Wild A, Beck S, Savasta S, Beluffi G, Ziegler A, Volz A (1999). "Genomic organization of the HSET locus and the possible association of HLA-linked genes with immotile cilia syndrome (ICS)". Immunogenetics. 49 (7–8): 644–652. doi:10.1007/s002510050660. PMID 10369922. S2CID 25729892.
  • Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis" (PDF). J. Cell Biol. 162 (5): 863–875. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
  • Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–172. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Al-Bassam J, Roger B, Halpain S, Milligan RA (2007). "Analysis of the weak interactions of ADP-Unc104 and ADP-kinesin with microtubules and their inhibition by MAP2c". Cell Motil. Cytoskeleton. 64 (5): 377–389. doi:10.1002/cm.20190. PMID 17326138.

External links edit

  • Overview of all the structural information available in the PDB for UniProt: Q9BW19 (Human Kinesin-like protein KIFC1) at the PDBe-KB.