28S ribosomal protein S30, mitochondrial is a protein that in humans is encoded by the MRPS30 gene.[5][6][7]
MRPS30 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | MRPS30, MRP-S30, PAP, PDCD9, S30mt, mitochondrial ribosomal protein S30 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 611991 MGI: 1926237 HomoloGene: 9607 GeneCards: MRPS30 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that is similar to the chicken pro-apoptotic protein p52. Transcript variants using alternative promoters or polyA sites have been mentioned in the literature but the complete description of these sequences is not available.[7]