Peiris's research interest is in emerging viral diseases, especially those passed from animals to humans, using a multidisciplinary approach termed "One-Health", which Peiris has defined as a "collaboration between the animal health, environmental health, human health, and laboratory sectors."[13]
Currently at HKU, Malik is the Tam Wah-Ching Professor in Medical Science and Chair Professor of Virology at the Division of Public health Laboratory Sciences, School of Public Health.[7] Since 2021, he has been working part time. He is also a co-director of the WHO H5 Reference Laboratory and the WHO SARS-CoV-2 reference laboratory,[7] the Director of Centre of Influenza Research[17] and the managing director of the centre for Immunology and Infection.[18] He retired from the position of co-director of the HKU-Pasteur Research Pole, jointly created in 2000 by HKU and the Pasteur Institute in France,[19] and became an Honorary Director.[17]
In 1997, after the first human outbreak of the avian influenzaH5N1 virus in Hong Kong, Peiris turned his attention to the virus, which claimed the lives of a third of its victims. Research in his group showed that the virus induces a high level of cytokines when a type of white blood cell called macrophage is infected.[26] This so-called "cytokine storm" is now recognized as a major mechanism of avian influenza virus pathogenesis.[27][28]
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^Lau, Yu Lung; Peiris, JS Malik (2005). "Pathogenesis of severe acute respiratory syndrome". Current Opinion in Immunology. 17 (4): 404–410. doi:10.1016/j.coi.2005.05.009. PMC7127490. PMID 15950449.
^Normile, Dennis (2003). "Up Close and Personal With SARS". Science. 300 (5621): 886–887. doi:10.1126/science.300.5621.886. PMID 12738826. S2CID 58433622.
^Poon, Leo LM; Wong, On Kei; Luk, Winsie; Yuen, Kwok Yung; Peiris, Joseph SM; Guan, Yi (2003). "Rapid Diagnosis of a Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS)". Clinical Chemistry. 49 (6): 953–955. doi:10.1373/49.6.953. PMC7108127. PMID 12765993.
^Poon, Leo L.M.; Peiris, Malik (2020). "Emergence of a novel human coronavirus threatening human health". Nature Medicine. 26 (3): 317–319. doi:10.1038/s41591-020-0796-5. PMC7095779. PMID 32108160.
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^Chin, Alex WH; Chu, Julie TS; Perera, Mahen RA; Hui, Kenrie PY; Yen, Hui-Ling; Chan, Michael CW; Peiris, Malik; Poon, Leo LM (2020). "Stability of SARS-CoV-2 in different environmental conditions". The Lancet Microbe. 1 (1): e10. doi:10.1016/S2666-5247(20)30003-3. PMC7214863. PMID 32835322.
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