Neurotensin receptor type 1 is a protein that in humans is encoded by the NTSR1 gene.[5][6] For a crystal structure of NTS1, see pdb code 4GRV. In addition, high-resolution crystal structures have been determined in complex with the peptide full agonist NTS8-13, the non-peptide full agonist SRI-9829, the partial agonist RTI-3a, and the antagonists / inverse agonists SR48692 and SR142948A, as well as in the ligand-free apo state.[7], see PDB codes 6YVR (NTSR1-H4X:NTS8–13), 6Z4V (NTSR1-H4bmX:NTS8–13), 6Z8N (NTSR1-H4X:SRI-9829), 6ZA8 (NTSR1-H4X:RTI-3a), 6Z4S (NTSR1-H4bmX:SR48692), 6ZIN (NTSR1-H4X:SR48692), 6Z4Q (NTSR1-H4X: SR142948A), and 6Z66 (apo NTSR1-H4X).
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | NTSR1, NTR, Neurotensin receptor 1, neurotensin receptor 1 (high affinity), NTR1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 162651 MGI: 97386 HomoloGene: 68261 GeneCards: NTSR1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Neurotensin receptor 1, also called NTR1, belongs to the large superfamily of G-protein coupled receptors and is considered a class-A GPCR. NTSR1 mediates multiple biological processes through modulation by neurotensin, such as low blood pressure, high blood sugar, low body temperature, antinociception, anti-neuronal damage [8] and regulation of intestinal motility and secretion.[6]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.