OR11H4 Knowpia

OR11H4
Identifiers
Aliases	OR11H4, OR14-36, olfactory receptor family 11 subfamily H member 4
External IDs	MGI: 3030583 HomoloGene: 10652 GeneCards: OR11H4
Gene location (Human)
Chr.	Chromosome 14 (human)
End	20,244,349 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	50,982,551 bp
RNA expression pattern
	Top expressed in
	superior frontal gyrus; ; endometrium; ; caudate nucleus;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity; G protein-coupled serotonin receptor activity; neurotransmitter receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; dendrite;
Biological process	sensory perception of smell; detection of chemical stimulus involved in sensory perception of smell; signal transduction; response to stimulus; G protein-coupled serotonin receptor signaling pathway; G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; chemical synaptic transmission;
	Sources:Amigo / QuickGO
Orthologs
	390442
	56858
	ENSG00000176198
	ENSMUSG00000059069
	Q8NGC9
	E9Q438
	NM_001004479
	NM_020288
	NP_001004479
	NP_064684
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 11H4 is a protein that in humans is encoded by the OR11H4 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands edit

Isovaleric acid^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000176198 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059069 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR11H4 olfactory receptor, family 11, subfamily H, member 4".
^ Menashe I, Abaffy T, Hasin Y, Goshen S, Yahalom V, Luetje CW, Lancet D (October 2007). "Genetic elucidation of human hyperosmia to isovaleric acid". PLOS Biology. 5 (11): e284. doi:10.1371/journal.pbio.0050284. PMC 2043052. PMID 17973576.