OR1A1 Knowpia

OR1A1
Identifiers
Aliases	OR1A1, OR17-7, olfactory receptor family 1 subfamily A member 1, olfactory receptor family 1 subfamily A member 1 (gene/pseudogene)
External IDs	OMIM: 618046 MGI: 1333770 HomoloGene: 8219 GeneCards: OR1A1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,218,896 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	74,102,205 bp
RNA expression pattern
	Top expressed in
	gonad; ; male reproductive system; ; testicle;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; olfactory receptor activity; G protein-coupled receptor activity;
Cellular component	plasma membrane; membrane; integral component of membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8383
	258706
	ENSG00000172146
	ENSMUSG00000070377
	Q9P1Q5
	n/a
	NM_014565; NM_001386104
	NM_146711
	NP_055380
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 1A1 is a protein that in humans is encoded by the OR1A1 gene.^[5]^[6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[6]

Ligands edit

OR1A1 is relatively broadly tuned, meaning it responds to a relatively wide variety of different odor molecules.^[7]^[8] Examples of known ligands, most of which have citrus or fruity smells:^[9]^[10]

(S)-(−)-citronellal
Helional
Heptanal
Octanal
Nonanal (weaker than heptanal/octanal^[9])
Hydroxycitronellal
Citral
Citronellol (both enantiomers, weaker than citronellal^[9])
Dihydrojasmone^[7]
Thiols^[8]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172146 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070377 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glusman G, Sosinsky A, Ben-Asher E, Avidan N, Sonkin D, Bahar A, et al. (January 2000). "Sequence, structure, and evolution of a complete human olfactory receptor gene cluster". Genomics. 63 (2): 227–45. doi:10.1006/geno.1999.6030. PMID 10673334. S2CID 23416814.
^ ^a ^b "Entrez Gene: OR1A1 olfactory receptor, family 1, subfamily A, member 1".
^ ^a ^b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
^ ^a ^b Block E, Batista VS, Matsunami H, Zhuang H, Ahmed L (May 2017). "The role of metals in mammalian olfaction of low molecular weight organosulfur compounds". Natural Product Reports. 34 (5): 529–557. doi:10.1039/c7np00016b. PMC 5542778. PMID 28471462.
^ ^a ^b ^c Schmiedeberg K, Shirokova E, Weber HP, Schilling B, Meyerhof W, Krautwurst D (September 2007). "Structural determinants of odorant recognition by the human olfactory receptors OR1A1 and OR1A2". Journal of Structural Biology. 159 (3): 400–12. doi:10.1016/j.jsb.2007.04.013. PMID 17601748.
^ Audouze K, Tromelin A, Le Bon AM, Belloir C, Petersen RK, Kristiansen K, et al. (2014). "Identification of odorant-receptor interactions by global mapping of the human odorome". PLOS ONE. 9 (4): e93037. Bibcode:2014PLoSO...993037A. doi:10.1371/journal.pone.0093037. PMC 3973694. PMID 24695519.