OR2C1 Knowpia

OR2C1
Identifiers
Aliases	OR2C1, OLFmf3, OR2C2P, olfactory receptor family 2 subfamily C member 1
External IDs	MGI: 106182 HomoloGene: 7459 GeneCards: OR2C1
Gene location (Human)
Chr.	Chromosome 16 (human)
End	3,357,306 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	3,662,611 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; uterine tube; ; right uterine tube; ; lymph node; ; islet of Langerhans; ; spinal cord; ; endometrium; ; Brodmann area 9; ; kidney;
	Top expressed in
	Jacobson's organ; ; respiratory epithelium; ; olfactory epithelium; ; skin of abdomen;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; olfactory receptor activity; odorant binding;
Cellular component	integral component of membrane; plasma membrane; membrane; cell cortex;
Biological process	signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; sensory perception of smell; G protein-coupled receptor signaling pathway; detection of chemical stimulus involved in sensory perception;
	Sources:Amigo / QuickGO
Orthologs
	4993
	18312
	ENSG00000168158
	ENSMUSG00000059043
	O95371
	P23275
	NM_012368
	NM_008762
	NP_036500
	NP_032788
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 2C1 is a protein that in humans is encoded by the OR2C1 gene.^[5]^[6]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[6]

Ligands edit

Octanethiol^[7]
Nonanethiol^[7]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168158 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059043 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Centola M, Chen X, Sood R, Deng Z, Aksentijevich I, Blake T, Ricke DO, Chen X, Wood G, Zaks N, Richards N, Krizman D, Mansfield E, Apostolou S, Liu J, Shafran N, Vedula A, Hamon M, Cercek A, Kahan T, Gumucio D, Callen DF, Richards RI, Moyzis RK, Doggett NA, Collins FS, Liu PP, Fischel-Ghodsian N, Kastner DL (Jan 1999). "Construction of an ~700-kb Transcript Map Around the Familial Mediterranean Fever Locus on Human Chromosome 16p13.3". Genome Res. 8 (11): 1172–91. doi:10.1101/gr.8.11.1172. PMC 310791. PMID 9847080.
^ ^a ^b "Entrez Gene: OR2C1 olfactory receptor, family 2, subfamily C, member 1".
^ ^a ^b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.