OR3A1 Knowpia

OR3A1
Identifiers
Aliases	OR3A1, OLFRA03, OR17-40, OR17-82, OR40, olfactory receptor family 3 subfamily A member 1, olfactory receptor family 3 subfamily A member 1 (gene/pseudogene)
External IDs	MGI: 3030236 HomoloGene: 1915 GeneCards: OR3A1
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,298,360 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	74,048,987 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; islet of Langerhans; ; prefrontal cortex; ; urinary bladder; ; testicle; ; gallbladder; ; adrenal gland;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; signal transducer activity; olfactory receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	4994
	258703
	ENSG00000180090
	ENSMUSG00000070379
	P47881
	Q8VFX8
	NM_002550
	NM_146708
	NP_002541
	NP_666919
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.^[5]^[6]^[7]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[7]

Ligands edit

OR3A1 is activated by helional and the closely related molecule heliotropylacetone.^[8] Other compounds including piperonal, safrole, and vanillin completely failed to activate OR3A1.

Agonists:

helional^[8]
heliotropylacetone^[8]
lilial^[9]
cyclamen aldehyde^[9]
foliaver (3-(4-methoxyphenyl)-2-methylpropanal)^[9]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180090 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070379 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Glusman G, Clifton S, Roe B, Lancet D (October 1996). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386.
^ Crowe ML, Perry BN, Connerton IF (March 1996). "Olfactory receptor-encoding genes and pseudogenes are expressed in humans". Gene. 169 (2): 247–9. doi:10.1016/0378-1119(95)00849-7. PMID 8647456.
^ ^a ^b "Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1".
^ ^a ^b ^c Sanz G, Schlegel C, Pernollet JC, Briand L (January 2005). "Comparison of odorant specificity of two human olfactory receptors from different phylogenetic classes and evidence for antagonism". Chemical Senses. 30 (1): 69–80. doi:10.1093/chemse/bji002. PMID 15647465.
^ ^a ^b ^c Jacquier V, Pick H, Vogel H (April 2006). "Characterization of an extended receptive ligand repertoire of the human olfactory receptor OR17-40 comprising structurally related compounds". Journal of Neurochemistry. 97 (2): 537–44. doi:10.1111/j.1471-4159.2006.03771.x. PMID 16539658. S2CID 22179276.