OR51E1 Knowpia

OR51E1
Identifiers
Aliases	OR51E1, D-GPCR, DGPCR, GPR136, GPR164, OR51E1P, OR52A3P, POGR, PSGR2, olfactory receptor family 51 subfamily E member 1
External IDs	OMIM: 611267 MGI: 3030392 HomoloGene: 17503 GeneCards: OR51E1
Gene location (Human)
Chr.	Chromosome 11 (human)
End	4,655,488 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	102,361,271 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; tibialis anterior muscle; ; pancreatic ductal cell; ; popliteal artery; ; left ventricle; ; placenta; ; prostate; ; abdominal fat; ; right coronary artery; ; smooth muscle tissue;
	Top expressed in
	esophagus; ; spermatocyte; ; spermatid; ; artery; ; muscle tissue; ; skeletal muscle tissue; ; carotid body; ; major salivary gland; ; duodenum; ; submandibular gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	signal transducer activity; olfactory receptor activity; G protein-coupled receptor activity;
Cellular component	membrane; integral component of membrane; plasma membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	143503
	259097
	ENSG00000180785
	ENSMUSG00000070423
	Q8TCB6
	Q8VGZ7
	NM_152430
	NM_147093
	NP_689643
	NP_667304
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 51E1 is a protein that in humans is encoded by the OR51E1 gene.^[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.^[5]

Ligands edit

The receptor is associated with some compounds with a "cheese" or "sour" scent note. Examples of compounds that activate OR51E1 include:

butyl butyryl lactate^[6]
isovaleric acid^[7]
nonanoic acid^[6]
3-methylpentanoic acid^[8]
4-methylpentanoic acid^[8]

The following are in decreasing order of activity:^[9]

butyric acid
methyl eugenol
methyl salicylate
(+)-menthol
eugenyl acetate
2,4-dinitrotoluene
pyrazine
dimethyl disulfide
methyl furfuryl disulfide
pentanol
propanal

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180785 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070423 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR51E1 olfactory receptor, family 51, subfamily E, member 1".
^ ^a ^b Saito H, Chi Q, Zhuang H, Matsunami H, Mainland JD (March 2009). "Odor coding by a Mammalian receptor repertoire". Science Signaling. 2 (60): ra9. doi:10.1126/scisignal.2000016. PMC 2774247. PMID 19261596.
^ Mainland JD, Keller A, Li YR, Zhou T, Trimmer C, Snyder LL, et al. (January 2014). "The missense of smell: functional variability in the human odorant receptor repertoire". Nature Neuroscience. 17 (1): 114–20. doi:10.1038/nn.3598. PMC 3990440. PMID 24316890.
^ ^a ^b Fujita Y, Takahashi T, Suzuki A, Kawashima K, Nara F, Koishi R (2007). "Deorphanization of Dresden G protein-coupled receptor for an odorant receptor". Journal of Receptor and Signal Transduction Research. 27 (4): 323–34. doi:10.1080/10799890701534180. PMID 17885925. S2CID 42999502.
^ Adipietro KA, Mainland JD, Matsunami H (2012). "Functional evolution of mammalian odorant receptors". PLOS Genetics. 8 (7): e1002821. doi:10.1371/journal.pgen.1002821. PMC 3395614. PMID 22807691.