OR6A2 Knowpia

OR6A2
Identifiers
Aliases	OR6A2, I7, OR11-55, OR6A1, OR6A2P, olfactory receptor family 6 subfamily A member 2
External IDs	OMIM: 608495 MGI: 97432 HomoloGene: 2743 GeneCards: OR6A2
Gene location (Human)
Chr.	Chromosome 11 (human)
End	6,799,689 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	106,605,279 bp
RNA expression pattern
	Top expressed in
	organ system; ; reproductive system; ; reproductive organ; ; male reproductive system; ; gonad; ; testicle;
	Top expressed in
	Jacobson's organ; ; secondary oocyte; ; yolk sac; ; peripheral nervous system; ; vastus lateralis muscle; ; respiratory epithelium; ; olfactory epithelium;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; olfactory receptor activity; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; membrane;
Biological process	sensory perception of smell; signal transduction; response to stimulus; detection of chemical stimulus involved in sensory perception of smell; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	8590
	18317
	ENSG00000184933
	ENSMUSG00000070417
	O95222
	n/a
	NM_003696
	NM_010983
	NP_003687
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Olfactory receptor 6A2 is a protein that in humans is encoded by the OR6A2 gene.^[5] It is Class II (tetrapod-specific) olfactory receptor and a rhodopsin-like receptor.

Function edit

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitters and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals.^[5]

Clinical significance edit

Variation in the OR6A2 gene has been identified as a likely cause of why some people enjoy the smell and taste of coriander (also known as cilantro)^[6] while others have exactly the opposite reaction to the point of repulsion. Depending on ancestry, somewhere between 3% and 21% of the population associate it with unpleasant taste, including a combination of soap and vomit, or say that it is similar to the foul smelling odor emitted by stinkbugs. This is due to the presence of aldehyde chemicals,^[7] which are present in soap, various detergents, coriander, and several species of stinkbugs.^{[citation needed]}

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000184933 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070417 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: OR6A2 olfactory receptor, family 6, subfamily A, member 2".
^ Eriksson N; Wu S; Chuong BD; et al. (29 November 2012). "A genetic variant near olfactory receptor genes influences cilantro preference". Flavour. 1. arXiv:1209.2096. doi:10.1186/2044-7248-1-22. S2CID 199627.
^ Callaway E (September 2012). "Soapy taste of coriander linked to genetic variants". Nature. doi:10.1038/nature.2012.11398. S2CID 87980895.