omega-Atracotoxin (ω-atracotoxin) is an insect-specific neurotoxin produced by the Blue Mountains funnel-web spider. Its phylogenetic specificity derives from its ability to antagonise insect, but not vertebrate, voltage-gated calcium channels. Two spatially proximal amino acid residues, Asn(27) and Arg(35), form a contiguous molecular surface that is essential for toxin activity. It has been proposed that this surface of the beta-hairpin is a key site for interaction of the toxin with insect calcium channels.[1]
ω-Atracotoxin | |||||||||||
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Identifiers | |||||||||||
Symbol | Omega-toxin | ||||||||||
Pfam | PF06357 | ||||||||||
InterPro | IPR009415 | ||||||||||
SCOP2 | 1hvw / SCOPe / SUPFAM | ||||||||||
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