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PEX11B

Summary

Peroxisomal membrane protein 11B is a protein that in humans is encoded by the PEX11B gene.[5][6] It is involved in the regulation of peroxisome abundance. [7]

PEX11B
Identifiers
AliasesPEX11B, PEX11-BETA, PEX14B, peroxisomal biogenesis factor 11 beta, PEX11beta
External IDsOMIM: 603867 MGI: 1338882 HomoloGene: 2852 GeneCards: PEX11B
Orthologs
SpeciesHumanMouse
Entrez

8799

18632

Ensembl

ENSG00000131779

ENSMUSG00000028102

UniProt

O96011

Q9Z210

RefSeq (mRNA)

NM_001184795
NM_003846

NM_001162387
NM_001162388
NM_011069

RefSeq (protein)

NP_001171724
NP_003837

NP_001155859
NP_001155860
NP_035199

Location (UCSC)Chr 1: 145.91 – 145.92 MbChr 3: 96.54 – 96.55 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse


Interactions edit

PEX11B has been shown to interact with PEX19.[8][9]

Related gene problems edit

References edit

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000131779 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028102 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schrader M, Reuber BE, Morrell JC, Jimenez-Sanchez G, Obie C, Stroh TA, Valle D, Schroer TA, Gould SJ (December 1998). "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli". J Biol Chem. 273 (45): 29607–14. doi:10.1074/jbc.273.45.29607. PMID 9792670.
  6. ^ "Entrez Gene: PEX11B peroxisomal biogenesis factor 11B".
  7. ^ Thoms S, Erdmann R (October 2005). "Dynamin-related proteins and Pex11 proteins in peroxisome division and proliferation". FEBS J. 272 (20): 5169–81. doi:10.1111/j.1742-4658.2005.04939.x. PMID 16218949. S2CID 33237347.
  8. ^ Sacksteder KA, Jones J M, South S T, Li X, Liu Y, Gould S J (March 2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. ISSN 0021-9525. PMC 2174547. PMID 10704444.
  9. ^ Fransen M, Wylin T, Brees C, Mannaerts G P, Van Veldhoven P P (July 2001). "Human Pex19p Binds Peroxisomal Integral Membrane Proteins at Regions Distinct from Their Sorting Sequences". Mol. Cell. Biol. 21 (13): 4413–24. doi:10.1128/MCB.21.13.4413-4424.2001. ISSN 0270-7306. PMC 87101. PMID 11390669.

Further reading edit

  • Abe I, Fujiki Y (1998). "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p". Biochem. Biophys. Res. Commun. 252 (2): 529–33. doi:10.1006/bbrc.1998.9684. PMID 9826565.
  • Sacksteder KA, Jones JM, South ST, et al. (2000). "Pex19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis". J. Cell Biol. 148 (5): 931–44. doi:10.1083/jcb.148.5.931. PMC 2174547. PMID 10704444.
  • Fransen M, Brees C, Ghys K, et al. (2002). "Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay". Mol. Cell. Proteomics. 1 (3): 243–52. doi:10.1074/mcp.M100025-MCP200. PMID 12096124.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Li X, Gould SJ (2003). "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11". J. Biol. Chem. 278 (19): 17012–20. doi:10.1074/jbc.M212031200. PMID 12618434.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Kobayashi S, Tanaka A, Fujiki Y (2007). "Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesis". Exp. Cell Res. 313 (8): 1675–86. doi:10.1016/j.yexcr.2007.02.028. PMID 17408615.