PIK3R4 Knowpia

PIK3R4
Identifiers
Aliases	PIK3R4, VPS15, p150, phosphoinositide-3-kinase regulatory subunit 4
External IDs	OMIM: 602610 MGI: 1922919 HomoloGene: 24678 GeneCards: PIK3R4
Gene location (Human)
Chr.	Chromosome 3 (human)
End	130,746,829 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	105,564,856 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; anterior pituitary; ; right lobe of thyroid gland; ; Brodmann area 9; ; left lobe of thyroid gland; ; upper lobe of left lung; ; right lung; ; tibial nerve; ; skin of abdomen; ; right coronary artery;
	Top expressed in
	secondary oocyte; ; motor neuron; ; medullary collecting duct; ; iris; ; facial motor nucleus; ; primitive streak; ; semi-lunar valve; ; retinal pigment epithelium; ; supraoptic nucleus; ; trigeminal ganglion;
	More reference expression data
	n/a
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; 1-phosphatidylinositol-3-kinase activity;
Cellular component	cytosol; endosome; late endosome; phagocytic vesicle membrane; membrane; phosphatidylinositol 3-kinase complex, class III; nuclear pore; autophagosome; phosphatidylinositol 3-kinase complex, class III, type I; axoneme; nucleus-vacuole junction; cytoplasmic vesicle; phosphatidylinositol 3-kinase complex, class III, type II; microtubule cytoskeleton; intracellular membrane-bounded organelle;
Biological process	cellular response to glucose starvation; regulation of cytokinesis; phosphorylation; late endosome to vacuole transport; autophagy of peroxisome; receptor catabolic process; positive regulation of phosphatidylinositol 3-kinase activity; protein phosphorylation; phosphatidylinositol biosynthetic process; protein targeting to vacuole; toll-like receptor 9 signaling pathway; macroautophagy; phosphatidylinositol-3-phosphate biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
	30849
	75669
	ENSG00000196455
	ENSMUSG00000032571
	Q99570
	Q8VD65
	NM_014602
	NM_001081309; NM_029380
	NP_055417
	NP_001074778
	Wikidata
View/Edit Human	View/Edit Mouse

Phosphoinositide 3-kinase regulatory subunit 4, also known as PI3-kinase regulatory subunit 4 or PI3-kinase p150 subunit or phosphoinositide 3-kinase adaptor protein, or VPS15 is an enzyme that in humans is encoded by the PIK3R4 gene.^[5]^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000196455 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032571 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Homo sapiens (human) ]".
^ Panaretou C, Domin J, Cockcroft S, Waterfield MD (January 1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.

Further reading edit

Askham JM, Vaughan KT, Goodson HV, Morrison EE (2002). "Evidence That an Interaction between EB1 and p150Glued Is Required for the Formation and Maintenance of a Radial Microtubule Array Anchored at the Centrosome". Mol. Biol. Cell. 13 (10): 3627–45. doi:10.1091/mbc.E02-01-0061. PMC 129971. PMID 12388762.
Koyasu S (2003). "The role of PI3K in immune cells". Nat. Immunol. 4 (4): 313–9. doi:10.1038/ni0403-313. PMID 12660731. S2CID 9951653.
Matsunaga K, Saitoh T, Tabata K, et al. (2009). "Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages". Nat. Cell Biol. 11 (4): 385–96. doi:10.1038/ncb1846. PMID 19270696. S2CID 205286778.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence Comparison of Human and Mouse Genes Reveals a Homologous Block Structure in the Promoter Regions". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Takeshita F, Gursel I, Ishii KJ, et al. (2004). "Signal transduction pathways mediated by the interaction of CpG DNA with Toll-like receptor 9". Semin. Immunol. 16 (1): 17–22. doi:10.1016/j.smim.2003.10.009. PMID 14751759.
Ligon LA, Shelly SS, Tokito M, Holzbaur EL (2003). "The Microtubule Plus-End Proteins EB1 and Dynactin Have Differential Effects on Microtubule Polymerization". Mol. Biol. Cell. 14 (4): 1405–17. doi:10.1091/mbc.E02-03-0155. PMC 153110. PMID 12686597.
Yan Y, Flinn RJ, Wu H, et al. (2009). "hVps15, but not Ca2+/CaM, is required for the activity and regulation of hVps34 in mammalian cells". Biochem. J. 417 (3): 747–55. doi:10.1042/BJ20081865. PMC 2652830. PMID 18957027.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000196455 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032571 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "PIK3R4 phosphoinositide-3-kinase regulatory subunit 4 [ Homo sapiens (human) ]".

[pmid8999962-6] Panaretou C, Domin J, Cockcroft S, Waterfield MD (January 1997). "Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex". J. Biol. Chem. 272 (4): 2477–85. doi:10.1074/jbc.272.4.2477. PMID 8999962.

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Summary

References edit

Further reading edit