PRIM2 Knowpia

PRIM2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3L9Q, 3Q36, 4BPU, 4BPW, 4BPX, 4RR2, 5F0Q, 5EXR, 5F0S
Identifiers
Aliases	PRIM2, PRIM2A, p58, primase (DNA) subunit 2, DNA primase subunit 2
External IDs	OMIM: 176636 MGI: 97758 HomoloGene: 731 GeneCards: PRIM2
Gene location (Human)
Chr.	Chromosome 6 (human)
End	57,646,850 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	33,708,876 bp
RNA expression pattern
	Top expressed in
	ganglionic eminence; ; Achilles tendon; ; oocyte; ; stromal cell of endometrium; ; rectum; ; sural nerve; ; islet of Langerhans; ; bone marrow cells; ; monocyte; ; lymph node;
	Top expressed in
	secondary oocyte; ; maxillary prominence; ; medial ganglionic eminence; ; cumulus cell; ; spermatocyte; ; dermis; ; mucous cell of stomach; ; abdominal wall; ; endocardial cushion; ; primitive streak;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-directed 5'-3' RNA polymerase activity; transferase activity; DNA binding; 4 iron, 4 sulfur cluster binding; iron-sulfur cluster binding; nucleotidyltransferase activity; metal ion binding; single-stranded DNA binding; DNA-directed DNA polymerase activity; DNA primase activity; protein binding;
Cellular component	nucleoplasm; alpha DNA polymerase:primase complex;
Biological process	DNA replication; DNA replication, synthesis of RNA primer; DNA biosynthetic process; telomere maintenance via semi-conservative replication; G1/S transition of mitotic cell cycle; DNA replication initiation;
	Sources:Amigo / QuickGO
Orthologs
	5558
	19076
	ENSG00000146143
	ENSMUSG00000026134
	P49643
	P33610
	NM_000947; NM_001282487; NM_001282488
	NM_008922
	NP_000938; NP_001269416; NP_001269417
	NP_032948
	Wikidata
View/Edit Human	View/Edit Mouse

DNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.^[5]^[6]

The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.^[6]

References edit

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000146143 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026134 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). "Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12". Genomics. 28 (2): 350–3. doi:10.1006/geno.1995.1155. PMID 8530050.
^ ^a ^b "Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa".