His primary schooling consisted of Greek and Latin and very little modern science.[4] He later developed his interest in science at the University of Vienna, where he received his Ph.D. in chemistry in 1969 and his M.S. in pharmacy in 1970. He was a postdoctoral fellow at the Roche Institute of Molecular Biology from 1970 until 1971 when he joined the Department of Microbiology at the Icahn School of Medicine at Mount Sinai as an assistant professor.[1][5]
Researchedit
Palese's research covers RNA-containing viruses with a particular focus on influenza viruses/vaccines.[6]
When viruses infect cells, they respond with antiviral interferons -- Palese and Adolfo García-Sastre showed that most negative-strand RNA viruses counteract that antiviral response with protein antagonists to interferons. His work on "fundamental questions concerning the genetic make-up and biology of viruses" and virus-host interactions "uses molecular biological techniques to understand how viruses replicate and how they interact with cells to cause disease in their hosts", with emphasis on "the study of RNA viruses, including influenza, paramyxo and corona (SARS) viruses".[1][9] He developed a new animal model (the guinea pig) for studying the transmission of influenza viruses.[10] Palese has been involved in developing novel vaccines against influenza viruses, including SARS-CoV-2. Several of these vaccine approaches have been in human trials. Also, an anti-cancer vaccine based on a Newcastle disease virus vector has been tested in humans.
As of 2022, Palese and his team are working on creating a universal influenza virus vaccine, and SARS-CoV-2, specifically for low and middle-income countries.[11]
Patentsedit
Palese is named on 73 patents on Pubchem. As of 2023, recent patents include:
NAME
DATE GRANTED
PATENT NUMBER
Anti-Influenza B Virus Neuraminidase Antibodies And Uses Thereof
Palese, P., Roizman, B., eds. Genetic Variation of Viruses. New York: The New York Academy of Sciences; 1980. ISBN 0897660986
Palese, P., Kingsbury, D.W., eds. Genetics of Influenza Viruses. New York: Springer-Verlag; 1983. ISBN 978-3-7091-8706-7, 978-3-7091-8708-1
Palese, P., Roizman, B., eds. Genetic Engineering of Viruses and Viral Vectors. Washington, D.C.: National Academy of Sciences; 1997.[26]
Basler, C., Palese, P. Modulation of Innate Immunity by Filoviruses. In: Klenk, H., Feldmann, H., eds. Ebola and Marburg Viruses, Molecular and Cellular Biology. Chap 11. Abingdon, Oxfordshire, UK: BIOS Scientific Publishers; 2004:305-50. ISBN 0954523237
Palese, P., ed. Modulation of Host Gene Expression and Innate Immunity by Viruses. The Netherlands: Springer; 2005. ISBN 1402032412
Taubenberger, J.K., Palese, P. The Origin and Virulence of the 1918 Spanish Influenza Virus. In: Kawaoka, Y., ed. Influenza Virology Current Topics. Wymondham, UK: Caister Academic Press; 2006. ISBN 978-1-904455-06-6
Shaw, M.L. and Palese, P. Orthomyxoviruses: Molecular Biology. In: Mahy, B.W.J. and Van Regenmortel, M.H.V., eds. Encyclopedia of Virology, 3rd ed. Oxford: Elsevier; 2008:483-489. ISBN 0123739357
Kopecky-Bromberg, S.A., Palese, P. Recombinant Vectors as Influenza Vaccines. In: Compans, R.W., Orenstein, W.A., eds. Vaccines for Pandemic Influenza. Springer-Verlag, Berlin Heidelberg; 2009:243-268. ISBN 978-3-540-92164-6
Pica, N., Palese, P. and Steel, J. Live Attenuated Influenza Virus Vaccines: NS1 Truncation as an Approach to Virus Attenuation. In: Dormitzer, P.R., Mandl, C.W. and Rappuoli, R., eds. Replicating Vaccines. Basel: Springer; 2011:195-221. ISBN 3034602766
Pica, N. and Palese, P. Toward a Universal Influenza Virus Vaccine: Prospects and Challenges. In: Annual Review of Medicine. 2013:15-28.[27]
Palese, P. Influenza and Its Viruses. In: Engleberg, N.C., DiRita, V., Dermody, T.S., eds. Schaechter’s Mechanisms of Microbial Disease, 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2013: chapter 36. ISBN 978-0-7817-8744-4
Krammer, F. and Palese, P. Orthomyxoviridae: The Viruses and their Replication. In: Knipe, D.M., Howley, P.M. et al., eds. Fields Virology, 7th ed. Philadelphia: Wolters Kluwer; 2021. ISBN 978-1-9751-1254-7
Articlesedit
According to Scinapse, as of 2023, Palese has an h-Index of 123, 506 publications and 52,000 citations.[28]
Partial list of peer-reviewed articles:
Palese, P. (1977). "The genes of influenza virus". Cell. 10 (1): 1–10. doi:10.1016/0092-8674(77)90133-7. PMID 837439. S2CID 6562438.
Buonagurio, D. A.; Nakada, S.; Parvin, J. D.; Krystal, M.; Palese, P.; Fitch, W. M. (1986). "Evolution of human influenza a viruses over 50 years: Rapid, uniform rate of change in NS gene". Science. 232 (4753): 980–982. Bibcode:1986Sci...232..980B. doi:10.1126/science.2939560. PMID 2939560.
Luytjes, W.; Krystal, M.; Enami, M.; Parvin, J. D.; Palese, P. (1989). "Amplification, expression, and packaging of foreign gene by influenza virus". Cell. 59 (6): 1107–1113. doi:10.1016/0092-8674(89)90766-6. PMID 2598262. S2CID 251545.
Enami, M.; Luytjes, W.; Krystal, M.; Palese, P. (1990). "Introduction of site-specific mutations into the genome of influenza virus". Proceedings of the National Academy of Sciences of the United States of America. 87 (10): 3802–3805. Bibcode:1990PNAS...87.3802E. doi:10.1073/pnas.87.10.3802. PMC53991. PMID 2339122.
Fitch, W. M.; Leiter, J. M.; Li, X. Q.; Palese, P. (1991). "Positive Darwinian evolution in human influenza a viruses". Proceedings of the National Academy of Sciences of the United States of America. 88 (10): 4270–4274. Bibcode:1991PNAS...88.4270F. doi:10.1073/pnas.88.10.4270. PMC51640. PMID 1840695.
García-Sastre, A.; Egorov, A.; Matassov, D.; Brandt, S.; Levy, D. E.; Durbin, J. E.; Palese, P.; Muster, T. (1998). "Influenza a virus lacking the NS1 gene replicates in interferon-deficient systems". Virology. 252 (2): 324–330. doi:10.1006/viro.1998.9508. PMID 9878611.
Fodor, E.; Devenish, L.; Engelhardt, O. G.; Palese, P.; Brownlee, G. G.; García-Sastre, A. (1999). "Rescue of Influenza a Virus from Recombinant DNA". Journal of Virology. 73 (11): 9679–9682. doi:10.1128/JVI.73.11.9679-9682.1999. PMC113010. PMID 10516084.
Talon, J.; Salvatore, M.; O'Neill, R. E.; Nakaya, Y.; Zheng, H.; Muster, T.; García-Sastre, A.; Palese, P. (2000). "Influenza a and B viruses expressing altered NS1 proteins: A vaccine approach". Proceedings of the National Academy of Sciences. 97 (8): 4309–4314. Bibcode:2000PNAS...97.4309T. doi:10.1073/pnas.070525997. PMC18238. PMID 10725408.
Tumpey, T. M.; Basler, C. F.; Aguilar, P. V.; Zeng, H.; Solórzano, A.; Swayne, D. E.; Cox, N. J.; Katz, J. M.; Taubenberger, J. K.; Palese, P.; García-Sastre, A. (2005). "Characterization of the Reconstructed 1918 Spanish Influenza Pandemic Virus". Science. 310 (5745): 77–80. Bibcode:2005Sci...310...77T. CiteSeerX10.1.1.418.9059. doi:10.1126/science.1119392. PMID 16210530. S2CID 14773861.
Lowen, A. C.; Mubareka, S.; Tumpey, T. M.; García-Sastre, A.; Palese, P. (2006). "The guinea pig as a transmission model for human influenza viruses". Proceedings of the National Academy of Sciences. 103 (26): 9988–9992. Bibcode:2006PNAS..103.9988L. doi:10.1073/pnas.0604157103. PMC1502566. PMID 16785447.
Zamarin, D.; Ortigoza, M. B.; Palese, P. (2006). "Influenza a Virus PB1-F2 Protein Contributes to Viral Pathogenesis in Mice". Journal of Virology. 80 (16): 7976–7983. doi:10.1128/JVI.00415-06. PMC1563817. PMID 16873254.
König, R.; Stertz, S.; Zhou, Y.; Inoue, A.; Hoffmann, H. -H.; Bhattacharyya, S.; Alamares, J. G.; Tscherne, D. M.; Ortigoza, M. B.; Liang, Y.; Gao, Q.; Andrews, S. E.; Bandyopadhyay, S.; De Jesus, P.; Tu, B. P.; Pache, L.; Shih, C.; Orth, A.; Bonamy, G.; Miraglia, L.; Ideker, T.; García-Sastre, A.; Young, J. A. T.; Palese, P.; Shaw, M. L.; Chanda, S. K. (2010). "Human Host Factors Required for Influenza Virus Replication". Nature. 463 (7282): 813–817. Bibcode:2010Natur.463..813K. doi:10.1038/nature08699. PMC2862546. PMID 20027183.
Wang, T. T.; Tan, G. S.; Hai, R.; Pica, N.; Petersen, E.; Moran, T. M.; Palese, P. (2010). m. Fouchier, Ron A. (ed.). "Broadly Protective Monoclonal Antibodies against H3 Influenza Viruses following Sequential Immunization with Different Hemagglutinins". PLOS Pathogens. 6 (2): e1000796. doi:10.1371/journal.ppat.1000796. PMC2829068. PMID 20195520.
Steel, J.; Lowen, A. C.; Wang, T. T.; Yondola, M.; Gao, Q.; Haye, K.; Garcia-Sastre, A.; Palese, P. (2010). "Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain". mBio. 1 (1): e00018–e00010. doi:10.1128/mBio.00018-10. PMC2912658. PMID 20689752.
Wang, T. T.; Tan, G. S.; Hai, R.; Pica, N.; Ngai, L.; Ekiert, D. C.; Wilson, I. A.; Garcia-Sastre, A.; Moran, T. M.; Palese, P. (2010). "Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes". Proceedings of the National Academy of Sciences. 107 (44): 18979–18984. Bibcode:2010PNAS..10718979W. doi:10.1073/pnas.1013387107. PMC2973924. PMID 20956293.
^TWiV 396: Influenza viruses with Peter Palese, July 3, 2016.
^"Robert-Koch-Stiftung – Lebensläufe der Preisträger". Retrieved March 4, 2011.
^"PNAS Member Editor Details". nrc88.nas.edu. Retrieved 2023-06-28.
^"Mount Sinai School of Medicine – Meet the Chair". Retrieved March 23, 2011.
^Lipchitz, Rebecca (September 28, 2005). "Lessons learned from the influenza pandemic of 1918". BU Today. Boston University. Archived from the original on June 28, 2011. Retrieved March 4, 2011.
^"Vivaldi Biosciences, Inc". Retrieved March 4, 2011.
^Knox, Richard (May 8, 2009). "Flu Heads South for the Winter". Retrieved March 8, 2011.
^"Peter Palese Ph.D." La Jolla Institute for Immunology. Retrieved 2023-06-28.
^"Anti-Influenza B Virus neuraminidase antibodies and uses thereof". Justia Patents.
^"US Patent Application for INFLUENZA VIRUS HEMAGGLUTININ PROTEINS AND USES THEREOF Patent Application (Application #20220257749 issued August 18, 2022) - Justia Patents Search". patents.justia.com. Retrieved 2023-03-28.
^"US Patent for Influenza virus vaccines and uses thereof Patent (Patent # 10,583,188 issued March 10, 2020) - Justia Patents Search". patents.justia.com. Retrieved 2023-03-28.
^"US Patent for Antibodies against influenza virus hemagglutinin and uses thereof Patent (Patent # 10,544,207 issued January 28, 2020) - Justia Patents Search". patents.justia.com. Retrieved 2023-03-28.
^"Springer Science & Business Media". Retrieved March 4, 2011.
^"ContraFect Corp. Scientific Board – Unprecedented expertise in the study of Influenza and other infectious diseases". Archived from the original on January 20, 2010. Retrieved March 4, 2011.
^"European Society for Virology". Archived from the original on July 20, 2011. Retrieved March 4, 2011.
^"Site Web Institut Pasteur - the 4 Award Winners 2012". Archived from the original on 2013-03-20. Retrieved 2015-02-12.
^"2016 ASM Microbe Award Winners". www.asm.org. Retrieved 2016-10-12.
^"IHV2017 | University of Maryland School of Medicine". www.ihv.org. Retrieved 2023-03-03.
^"IMMID International Symposium". College of Medicine. 2018-12-12. Retrieved 2023-03-03.
^"2016 ASM Microbe Award Winners". www.asm.org. Retrieved 2016-10-12.
^Palese, P; Roizman, B (1996-10-15). "Genetic engineering of viruses and of virus vectors: a preface". Proceedings of the National Academy of Sciences. 93 (21): 11287. Bibcode:1996PNAS...9311287P. doi:10.1073/pnas.93.21.11287. ISSN 0027-8424. PMC38049. PMID 8876127.
^Pica, Natalie; Palese, Peter (2013-01-14). "Toward a Universal Influenza Virus Vaccine: Prospects and Challenges". Annual Review of Medicine. 64 (1): 189–202. doi:10.1146/annurev-med-120611-145115. ISSN 0066-4219. PMID 23327522.
Swine Flu: H1N1 Interview with Dr. Peter Palese on 60 Minutes
TWiV 396: Influenza viruses with Peter Palese, July 3, 2016. Interview with Vincent Racaniello on his career in virology, from early work on neuraminidases to universal influenza virus vaccines.