Peter Wagener Grayson (1788–1838) was an attorney, diplomat, cabinet officer, and presidential candidate in the Republic of Texas. He was the son of Benjamin and Caroline (Taylor) Grayson, and was born in Bardstown, Virginia (later Kentucky), in 1788. He owned a plantation near Matagorda, Texas.

Grayson helped raise United States volunteers for the Texas Revolution, and he was appointed by President Sam Houston as Texas attorney general in February 1837 and as naval agent to the United States in December 1837.

In 1838, Grayson was the Houston party candidate for president of the Republic of Texas. On July 9 of that year he fatally shot himself.